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Target
NAD(P)H dehydrogenase [quinone] 1
Ligand
BDBM381847
Substrate
n/a
Meas. Tech.
BEAS-2B NQO1 MTT Assay
EC50
5500±n/a nM
Citation
 Kerns, JK; Callahan, JF; Yan, H; Heightman, TD; Boehm, JC; Woolford, AJ NRF2 regulators US Patent  US10272095 Publication Date 4/30/2019 
Target
Name:
NAD(P)H dehydrogenase [quinone] 1
Synonyms:
Azoreductase | DIA4 | DT-diaphorase | Menadione reductase | NAD(P)H:quinone oxidoreductase 1 | NMOR1 | NQO1 | NQO1_HUMAN | Phylloquinone reductase | QR1 | Quinone Reductase 1 | Quinone reductase 1)
Type:
Homodimer
Mol. Mass.:
30874.82
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
274
Sequence:
MVGRRALIVLAHSERTSFNYAMKEAAAAALKKKGWEVVESDLYAMNFNPIISRKDITGKLKDPANFQYPAESVLAYKEGHLSPDIVAEQKKLEAADLVIFQFPLQWFGVPAILKGWFERVFIGEFAYTYAAMYDKGPFRSKKAVLSITTGGSGSMYSLQGIHGDMNVILWPIQSGILHFCGFQVLEPQLTYSIGHTPADARIQILEGWKKRLENIWDETPLYFAPSSLFDLNFQAGFLMKKEVQDEEKNKKFGLSVGHHLGKSIPTDNQIKARK
  
Inhibitor
Name:
BDBM381847
Synonyms:
3-[(3aR,8bS)-1-(cyclohexylmethyl)-2-oxo-1H,2H,3H,3aH,4H,8bH-indeno[1,2-b]pyrrol-7-yl]-5-(1-ethyl-1H-1,2,3-triazol-4-yl)pentanoic Acid | US10272095, Example 3
Type:
Small organic molecule
Emp. Form.:
C27H36N4O3
Mol. Mass.:
464.5997
SMILES:
CCn1cc(CCC(CC(O)=O)c2ccc3CC4CC(=O)N(CC5CCCCC5)C4c3c2)nn1
Structure:
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