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Target
Proline-rich AKT1 substrate 1
Ligand
BDBM386012
Substrate
n/a
Meas. Tech.
AKT Enzyme Assay
IC50
62±n/a nM
Citation
Lan, R; Huck, BR; Chen, X; Xiao, Y Heterocyclic derivatives as modulators of kinase activity US Patent US10287300 Publication Date 5/14/2019
More Info.:
Target
Name:
Proline-rich AKT1 substrate 1
Synonyms:
40 kDa proline-rich AKT substrate | AKT1S1 | AKTS1_HUMAN | PRAS40
Type:
PROTEIN
Mol. Mass.:
27368.40
Organism:
Homo sapiens (Human)
Description:
ChEMBL_664853
Residue:
256
Sequence:
MASGRPEELWEAVVGAAERFRARTGTELVLLTAAPPPPPRPGPCAYAAHGRGALAEAARRCLHDIALAHRAATAARPPAPPPAPQPPSPTPSPPRPTLAREDNEEDEDEPTETETSGEQLGISDNGGLFVMDEDATLQDLPPFCESDPESTDDGSLSEETPAGPPTCSVPPASALPTQQYAKSLPVSVPVWGFKEKRTEARSSDEENGPPSSPDLDRIAASMRALVLREAEDTQVFGDLPRPRLNTSDFQKLKRKY
Inhibitor
Name:
BDBM386012
Synonyms:
US10287300, Compound A18 | {2-(4-Chloro-3-fluoro-phenyl)-2-[4-(5,6,7,8-tetrahydro-pyrido[2,3-d]pyrimidin-4-yl)-piperazin-1-yl]-ethyl}-dimethylamine
Type:
Small organic molecule
Emp. Form.:
C21H28ClFN6
Mol. Mass.:
418.939
SMILES:
CN(C)CC(N1CCN(CC1)c1ncnc2NCCCc12)c1ccc(Cl)c(F)c1