Reaction Details
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Target
Complex of Baculoviral IAP repeat-containing protein 7 [63-159,S150G] and E3 ubiquitin-protein ligase XIAP [336-348]
Ligand
BDBM27942
Substrate
BDBM17342
Meas. Tech.
Fluorescence Polarization Affinity Measurements
pH
7.2±n/a
Temperature
295.15±n/a K
Ki
43±n/a nM
Citation
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More Info.:
Target
Name:
Complex of Baculoviral IAP repeat-containing protein 7 [63-159,S150G] and E3 ubiquitin-protein ligase XIAP [336-348]
Synonyms:
Chimeric protein of melanoma inhibitor of apoptosis protein and XIAP-BIR3 | ML-IAP-BIR | MLXBIR3SG
Type:
Chimeric Protein
Mol. Mass.:
14953.37
Organism:
Homo sapiens (Human)
Description:
Q96CA5[63-159,S150G],P98170[336-348]
Residue:
133
Sequence:
MGSSHHHHHHSSGEVPRGSHMLETEEEEEEGAGATLSRGPAFPGMGSEELRLASFYDWPLTAEVPPELLAAAGFFHTGHQDKVRCFFCYGGLQSWKRGDDPWTEHAKWFPGCQFLLRSKGQEYINNIHLTHSL
Inhibitor
Name:
BDBM27942
Synonyms:
(2S)-1-[(2S)-2-[(2S)-2-aminopropanamido]-3-methylbutanoyl]-N-(2,2-diphenylethyl)pyrrolidine-2-carboxamide | Ala-Val-Pro-2,2-diphenethylamine, 1
Type:
n/a
Emp. Form.:
C27H36N4O3
Mol. Mass.:
464.5997
SMILES:
CC(C)[C@H](NC(=O)[C@H](C)N)C(=O)N1CCC[C@H]1C(=O)NCC(c1ccccc1)c1ccccc1 |r|