Reaction Details Report a problem with these data
Target
Neuronal acetylcholine receptor subunit alpha-7
Ligand
BDBM397114
Substrate
n/a
Meas. Tech.
FlexStation-Ca2+ Influx Assay
EC50
>1000±n/a nM
Citation
 Maeng, CY; Jang, YK; Cha, SB; Shin, HW; Joung, CM; Yi, EJ Pharmaceutical composition comprising pyridone derivatives US Patent  US9987259 Publication Date 6/5/2018 
Target
Name:
Neuronal acetylcholine receptor subunit alpha-7
Synonyms:
ACHA7_HUMAN | CHRNA7 | Cholinergic, Nicotinic Alpha7 | NACHRA7 | Neuronal acetylcholine receptor protein alpha-7 subunit | Neuronal acetylcholine receptor subunit alpha-7 (nAChR-alpha 7) | Nicotinic acetylcholine receptor alpha-7 (alpha7 nAChR)
Type:
n/a
Mol. Mass.:
56448.33
Organism:
Homo sapiens (Human)
Description:
CHRNA7 (NACHRA7)
Residue:
502
Sequence:
MRCSPGGVWLALAASLLHVSLQGEFQRKLYKELVKNYNPLERPVANDSQPLTVYFSLSLLQIMDVDEKNQVLTTNIWLQMSWTDHYLQWNVSEYPGVKTVRFPDGQIWKPDILLYNSADERFDATFHTNVLVNSSGHCQYLPPGIFKSSCYIDVRWFPFDVQHCKLKFGSWSYGGWSLDLQMQEADISGYIPNGEWDLVGIPGKRSERFYECCKEPYPDVTFTVTMRRRTLYYGLNLLIPCVLISALALLVFLLPADSGEKISLGITVLLSLTVFMLLVAEIMPATSDSVPLIAQYFASTMIIVGLSVVVTVIVLQYHHHDPDGGKMPKWTRVILLNWCAWFLRMKRPGEDKVRPACQHKQRRCSLASVEMSAVAPPPASNGNLLYIGFRGLDGVHCVPTPDSGVVCGRMACSPTHDEHLLHGGQPPEGDPDLAKILEEVRYIANRFRCQDESEAVCSEWKFAACVVDRLCLMAFSVFTIICTIGILMSAPNFVEAVSKDFA
  
Inhibitor
Name:
BDBM397114
Synonyms:
N-(1-azabicyclo[2.2.2]octan-3-yl)-1-(5-chloro-2-pyridinyl)-6-oxo-3-pyridinecarboxamide | US10456385, Example 6 | US9987259, Example 6
Type:
Small organic molecule
Emp. Form.:
C18H19ClN4O2
Mol. Mass.:
358.822
SMILES:
Clc1ccc(nc1)-n1cc(ccc1=O)C(=O)NC1CN2CCC1CC2 |(-7.34,2.7,;-6,1.92,;-4.67,2.69,;-3.33,1.92,;-3.33,.38,;-4.67,-.39,;-6,.38,;-2,-.39,;-.67,.38,;.67,-.39,;.67,-1.93,;-.67,-2.7,;-2,-1.93,;-3.33,-2.7,;2,.38,;2,1.92,;3.33,-.39,;4.67,.38,;4.67,1.93,;6,2.7,;7.34,1.93,;7.34,.38,;6,-.39,;6.72,1.36,;5.23,1.36,)|
Structure:
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