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Target
Isoform Bcl-X(L) of Bcl-2-like protein 1 (Bcl-xL)
Ligand
BDBM32269
Substrate
F-Bim
Meas. Tech.
Multiplexed dose response screen for small molecule regulators of Bcl-2 family protein interactions, specifically Bim-Bcl-XL.
pH
7.4±n/a
Temperature
277.15±n/a K
EC50
7170±n/a nM
Citation
 PubChem, PC Multiplexed dose response screen for small molecule regulators of Bcl-2 family protein interactions, specifically Bim-Bcl-XL. PubChem Bioassay (2008)[AID] 
Target
Name:
Isoform Bcl-X(L) of Bcl-2-like protein 1 (Bcl-xL)
Synonyms:
B-cell lymphoma-extra large protein (Bcl-xL) | B2CL1_HUMAN | BCL-xL | BCL2L | BCL2L1 | BCLX | Bcl-2-like protein 1 (Bcl-xL) | Isoform Bcl-X(L)
Type:
Homodimers/heterodimers with BAX, BAK and BCL2
Mol. Mass.:
26053.63
Organism:
Homo sapiens (Human)
Description:
gi_510901
Residue:
233
Sequence:
MSQSNRELVVDFLSYKLSQKGYSWSQFSDVEENRTEAPEGTESEMETPSAINGNPSWHLADSPAVNGATAHSSSLDAREVIPMAAVKQALREAGDEFELRYRRAFSDLTSQLHITPGTAYQSFEQVVNELFRDGVNWGRIVAFFSFGGALCVESVDKEMQVLVSRIAAWMATYLNDHLEPWIQENGGWDTFVELYGNNAAAESRKGQERFNRWFLTGMTVAGVVLLGSLFSRK
  
Inhibitor
Name:
BDBM32269
Synonyms:
3-(3-pyridinyl)-6-thiophen-2-yl-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazine | 3-(3-pyridyl)-6-(2-thienyl)-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazine | 3-pyridin-3-yl-6-thien-2-yl-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazine | 3-pyridin-3-yl-6-thiophen-2-yl-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazine | MLS000094784 | SMR000030337 | cid_3242602
Type:
Small organic molecule
Emp. Form.:
C13H9N5S2
Mol. Mass.:
299.374
SMILES:
C1Sc2nnc(-c3cccnc3)n2N=C1c1cccs1 |c:15|
Structure:
Search PDB for entries with ligand similarity:
Substrate
Name:
F-Bim
Synonyms:
n/a
Type:
fluorescent peptide probe
Mol. Mass.:
3923.40
Organism:
n/a
Description:
n/a
Residue:
32
Sequence:
FITCAHDMRPEIWIAQELRRIGDEFNAYYARH