Reaction Details Report a problem with these data
Target
Orexin receptor type 2
Ligand
BDBM402139
Substrate
n/a
Meas. Tech.
FLIPR Ca2+ Flux Assay
IC50
20.0±n/a nM
Citation
 Kim, RM; Kuduk, SD; Liverton, N; Zhou, G Ethyldiamine orexin receptor antagonists US Patent  US10011595 Publication Date 7/3/2018 
Target
Name:
Orexin receptor type 2
Synonyms:
HCRTR2 | Hypocretin receptor type 2 | OX2R_HUMAN | Orexin receptor type 2 (OR 2) | Orexin receptor type 2 (OR-2) | Orexin receptor type 2 (OX2) | Orexin receptor type 2 (OX2R) | Orexin receptor type 2 (OxR2) | Ox-2-R | Ox2-R
Type:
Protein
Mol. Mass.:
50710.53
Organism:
Homo sapiens (Human)
Description:
O43614
Residue:
444
Sequence:
MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARRKTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKLSEQVVLTSISTLPAANGAGPLQNW
  
Inhibitor
Name:
BDBM402139
Synonyms:
2-cyclopropyl-N-ethyl-N-(2- ((4-(2-hydroxypropan-2- yl)pyrimidin-2- yl)(methyl)amino)ethyl)-6- methoxynicotinamide | US10011595, H-28
Type:
Small organic molecule
Emp. Form.:
C22H31N5O3
Mol. Mass.:
413.5132
SMILES:
CCN(CCN(C)c1nccc(n1)C(C)(C)O)C(=O)c1ccc(OC)nc1C1CC1
Structure:
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