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Target
ATP-sensitive inward rectifier potassium channel 1
Ligand
BDBM265062
Substrate
n/a
Meas. Tech.
Thallium Flux Assay
IC50
10.00±n/a nM
Citation
 Biswas, D; Ding, F; Dong, S; Gu, X; Jiang, J; Pasternak, A; Suzuki, T; Vacca, J; Xu, S Inhibitors of the renal outer medullary potassium channel US Patent  US9718808 Publication Date 8/1/2017 
Target
Name:
ATP-sensitive inward rectifier potassium channel 1
Synonyms:
ATP-regulated potassium channel ROM-K | ATP-regulated potassium channel ROMK | ATP-sensitive inward rectifier potassium channel 1 | Egl nine homolog 1 | KCNJ1 | KCNJ1_HUMAN | Potassium channel (ATP modulatory) | Potassium inwardly-rectifying channel, subfamily J, member 1 | ROMK1 | Renal Outer Medullary Potassium (ROMK1) | The Renal Outer Medullary Potassium (ROMK)
Type:
Enzyme Catalytic Domain
Mol. Mass.:
44809.08
Organism:
Homo sapiens (Human)
Description:
gi_223460826
Residue:
391
Sequence:
MNASSRNVFDTLIRVLTESMFKHLRKWVVTRFFGHSRQRARLVSKDGRCNIEFGNVEAQSRFIFFVDIWTTVLDLKWRYKMTIFITAFLGSWFFFGLLWYAVAYIHKDLPEFHPSANHTPCVENINGLTSAFLFSLETQVTIGYGFRCVTEQCATAIFLLIFQSILGVIINSFMCGAILAKISRPKKRAKTITFSKNAVISKRGGKLCLLIRVANLRKSLLIGSHIYGKLLKTTVTPEGETIILDQININFVVDAGNENLFFISPLTIYHVIDHNSPFFHMAAETLLQQDFELVVFLDGTVESTSATCQVRTSYVPEEVLWGYRFAPIVSKTKEGKYRVDFHNFSKTVEVETPHCAMCLYNEKDVRARMKRGYDNPNFILSEVNETDDTKM
  
Inhibitor
Name:
BDBM265062
Synonyms:
US9718808, 1
Type:
Small organic molecule
Emp. Form.:
C20H24N8O3
Mol. Mass.:
424.4564
SMILES:
CC1=C(COC1=O)N1CC[C@@]2(CC[C@@H](CC2)NCc2ccc(nn2)-n2cnnn2)C1=O |r,wU:10.32,wD:13.17,t:1,(7.14,2.52,;7.91,1.18,;7.44,-.28,;8.68,-1.19,;9.93,-.28,;9.45,1.18,;10.22,2.52,;6.1,-1.05,;5.63,-2.52,;4.09,-2.52,;3.61,-1.05,;2.52,-2.14,;1.03,-1.74,;.64,-.25,;1.73,.83,;3.21,.44,;-.85,.14,;-1.94,-.95,;-3.43,-.55,;-4.52,-1.64,;-6,-1.24,;-6.4,.25,;-5.31,1.34,;-3.83,.94,;-7.73,.63,;-8.98,-.27,;-10.22,.63,;-9.75,2.1,;-8.21,2.1,;4.86,-.15,;4.86,1.39,)|
Structure:
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