Reaction Details Report a problem with these data
Target
ATP-sensitive inward rectifier potassium channel 1
Ligand
BDBM265604
Substrate
n/a
Meas. Tech.
Thallium Flux Assay
IC50
24.0±n/a nM
Citation
 Biswas, D; Ding, F; Dong, S; Gu, X; Jiang, J; Pasternak, A; Suzuki, T; Vacca, J; Xu, S Inhibitors of the renal outer medullary potassium channel US Patent  US9718808 Publication Date 8/1/2017 
Target
Name:
ATP-sensitive inward rectifier potassium channel 1
Synonyms:
ATP-regulated potassium channel ROM-K | ATP-regulated potassium channel ROMK | ATP-sensitive inward rectifier potassium channel 1 | Egl nine homolog 1 | KCNJ1 | KCNJ1_HUMAN | Potassium channel (ATP modulatory) | Potassium inwardly-rectifying channel, subfamily J, member 1 | ROMK1 | Renal Outer Medullary Potassium (ROMK1) | The Renal Outer Medullary Potassium (ROMK)
Type:
Enzyme Catalytic Domain
Mol. Mass.:
44809.08
Organism:
Homo sapiens (Human)
Description:
gi_223460826
Residue:
391
Sequence:
MNASSRNVFDTLIRVLTESMFKHLRKWVVTRFFGHSRQRARLVSKDGRCNIEFGNVEAQSRFIFFVDIWTTVLDLKWRYKMTIFITAFLGSWFFFGLLWYAVAYIHKDLPEFHPSANHTPCVENINGLTSAFLFSLETQVTIGYGFRCVTEQCATAIFLLIFQSILGVIINSFMCGAILAKISRPKKRAKTITFSKNAVISKRGGKLCLLIRVANLRKSLLIGSHIYGKLLKTTVTPEGETIILDQININFVVDAGNENLFFISPLTIYHVIDHNSPFFHMAAETLLQQDFELVVFLDGTVESTSATCQVRTSYVPEEVLWGYRFAPIVSKTKEGKYRVDFHNFSKTVEVETPHCAMCLYNEKDVRARMKRGYDNPNFILSEVNETDDTKM
  
Inhibitor
Name:
BDBM265604
Synonyms:
US9718808, 70
Type:
Small organic molecule
Emp. Form.:
C19H23N7O3S
Mol. Mass.:
429.496
SMILES:
C[C@H]1C[C@@]2(CC[C@@H](CC2)NCc2cnc(s2)-n2cnnn2)C(=O)N1C1=CC(=O)OC1 |r,wU:3.23,1.0,wD:6.9,t:28,(7.12,-3.09,;5.78,-2.32,;4.32,-2.8,;3.41,-1.55,;2.64,-2.89,;1.1,-2.89,;.33,-1.55,;1.1,-.22,;2.64,-.22,;-1.15,-1.15,;-1.93,-2.49,;-3.41,-2.09,;-4.32,-3.34,;-5.78,-2.86,;-5.78,-1.32,;-4.32,-.84,;-7.12,-.55,;-8.58,-1.03,;-9.49,.22,;-8.58,1.47,;-7.12,.99,;4.32,-.31,;3.55,1.03,;5.78,-.78,;7.12,-.01,;7.12,1.53,;8.58,2,;9.35,3.34,;9.49,.76,;8.58,-.49,)|
Structure:
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