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Target
ATP-sensitive inward rectifier potassium channel 1
Ligand
BDBM266983
Substrate
n/a
Meas. Tech.
Thallium Flux Assay
IC50
32.0±n/a nM
Citation
 Biswas, D; Ding, F; Dong, S; Gu, X; Jiang, J; Pasternak, A; Suzuki, T; Vacca, J; Xu, S Inhibitors of the renal outer medullary potassium channel US Patent  US9718808 Publication Date 8/1/2017 
Target
Name:
ATP-sensitive inward rectifier potassium channel 1
Synonyms:
ATP-regulated potassium channel ROM-K | ATP-regulated potassium channel ROMK | ATP-sensitive inward rectifier potassium channel 1 | Egl nine homolog 1 | KCNJ1 | KCNJ1_HUMAN | Potassium channel (ATP modulatory) | Potassium inwardly-rectifying channel, subfamily J, member 1 | ROMK1 | Renal Outer Medullary Potassium (ROMK1) | The Renal Outer Medullary Potassium (ROMK)
Type:
Enzyme Catalytic Domain
Mol. Mass.:
44809.08
Organism:
Homo sapiens (Human)
Description:
gi_223460826
Residue:
391
Sequence:
MNASSRNVFDTLIRVLTESMFKHLRKWVVTRFFGHSRQRARLVSKDGRCNIEFGNVEAQSRFIFFVDIWTTVLDLKWRYKMTIFITAFLGSWFFFGLLWYAVAYIHKDLPEFHPSANHTPCVENINGLTSAFLFSLETQVTIGYGFRCVTEQCATAIFLLIFQSILGVIINSFMCGAILAKISRPKKRAKTITFSKNAVISKRGGKLCLLIRVANLRKSLLIGSHIYGKLLKTTVTPEGETIILDQININFVVDAGNENLFFISPLTIYHVIDHNSPFFHMAAETLLQQDFELVVFLDGTVESTSATCQVRTSYVPEEVLWGYRFAPIVSKTKEGKYRVDFHNFSKTVEVETPHCAMCLYNEKDVRARMKRGYDNPNFILSEVNETDDTKM
  
Inhibitor
Name:
BDBM266983
Synonyms:
US9718808, 112
Type:
Small organic molecule
Emp. Form.:
C25H30N6O3
Mol. Mass.:
462.5441
SMILES:
CN(Cc1ccc-2c(CCc3nnnn-23)c1)[C@H]1CC[C@@]2(CCN(C2=O)C2=C(C)C(=O)OC2)CC1 |r,wU:19.26,wD:16.18,c:29,(-1.29,1.49,;-.89,0,;-1.98,-1.09,;-3.47,-.69,;-3.63,.84,;-5.04,1.47,;-6.28,.57,;-6.12,-.97,;-7.37,-1.87,;-8.77,-1.24,;-8.94,.29,;-10.18,1.19,;-9.71,2.66,;-8.17,2.66,;-7.69,1.19,;-4.71,-1.59,;.59,-.4,;.99,-1.88,;2.48,-2.28,;3.57,-1.19,;4.05,-2.66,;5.59,-2.66,;6.06,-1.19,;4.82,-.29,;4.82,1.25,;7.4,-.42,;7.87,1.04,;7.1,2.38,;9.41,1.04,;10.18,2.38,;9.89,-.42,;8.64,-1.33,;3.17,.3,;1.68,.69,)|
Structure:
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