Reaction Details Report a problem with these data
Target
ATP-sensitive inward rectifier potassium channel 1
Ligand
BDBM266992
Substrate
n/a
Meas. Tech.
Thallium Flux Assay
IC50
23.0±n/a nM
Citation
 Biswas, D; Ding, F; Dong, S; Gu, X; Jiang, J; Pasternak, A; Suzuki, T; Vacca, J; Xu, S Inhibitors of the renal outer medullary potassium channel US Patent  US9718808 Publication Date 8/1/2017 
Target
Name:
ATP-sensitive inward rectifier potassium channel 1
Synonyms:
ATP-regulated potassium channel ROM-K | ATP-regulated potassium channel ROMK | ATP-sensitive inward rectifier potassium channel 1 | Egl nine homolog 1 | KCNJ1 | KCNJ1_HUMAN | Potassium channel (ATP modulatory) | Potassium inwardly-rectifying channel, subfamily J, member 1 | ROMK1 | Renal Outer Medullary Potassium (ROMK1) | The Renal Outer Medullary Potassium (ROMK)
Type:
Enzyme Catalytic Domain
Mol. Mass.:
44809.08
Organism:
Homo sapiens (Human)
Description:
gi_223460826
Residue:
391
Sequence:
MNASSRNVFDTLIRVLTESMFKHLRKWVVTRFFGHSRQRARLVSKDGRCNIEFGNVEAQSRFIFFVDIWTTVLDLKWRYKMTIFITAFLGSWFFFGLLWYAVAYIHKDLPEFHPSANHTPCVENINGLTSAFLFSLETQVTIGYGFRCVTEQCATAIFLLIFQSILGVIINSFMCGAILAKISRPKKRAKTITFSKNAVISKRGGKLCLLIRVANLRKSLLIGSHIYGKLLKTTVTPEGETIILDQININFVVDAGNENLFFISPLTIYHVIDHNSPFFHMAAETLLQQDFELVVFLDGTVESTSATCQVRTSYVPEEVLWGYRFAPIVSKTKEGKYRVDFHNFSKTVEVETPHCAMCLYNEKDVRARMKRGYDNPNFILSEVNETDDTKM
  
Inhibitor
Name:
BDBM266992
Synonyms:
US9718808, 121
Type:
Small organic molecule
Emp. Form.:
C24H27FN6O3
Mol. Mass.:
466.508
SMILES:
CN(Cc1ccc-2c(Cn3nnnc-23)c1F)[C@H]1CC[C@@]2(CCN(C3=C(C)C(=O)OC3)C2=O)CC1 |r,wD:19.22,16.18,c:26,(-.66,2.07,;-.66,.53,;-1.99,-.24,;-3.33,.53,;-3.33,2.07,;-4.66,2.84,;-6,2.07,;-6,.53,;-7.46,.06,;-8.37,1.3,;-9.83,1.78,;-9.83,3.32,;-8.37,3.79,;-7.46,2.55,;-4.66,-.24,;-4.66,-1.78,;.67,-.24,;.67,-1.78,;2.01,-2.55,;3.34,-1.78,;3.34,-3.32,;4.8,-3.79,;5.71,-2.55,;7.04,-1.78,;7.52,-.31,;6.75,1.02,;9.06,-.31,;9.83,1.02,;9.54,-1.78,;8.29,-2.68,;4.8,-1.3,;5.57,.03,;3.34,-.24,;2.01,.53,)|
Structure:
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