Reaction Details Report a problem with these data
Target
Streptokinase A
Ligand
BDBM54873
Substrate
n/a
Meas. Tech.
Absorbance Microorganism-Based Dose Response Followup to Identify Inhibitors of Streptokinase Expression
EC50
7588±1188 nM
Citation
 PubChem, PC Absorbance Microorganism-Based Dose Response Followup to Identify Inhibitors of Streptokinase Expression PubChem Bioassay (2009)[AID] 
Target
Name:
Streptokinase A
Synonyms:
STRP_STRP1 | ska | streptokinase A precursor
Type:
Enzyme Catalytic Domain
Mol. Mass.:
49924.80
Organism:
Streptococcus pyogenes M1 GAS
Description:
gi_15675770
Residue:
440
Sequence:
MKNYLSIGVIALLFALTFGTVKSVQAIAGYGWLPDRPPINNSQLVVSMAGIVEGTDKKVFINFFEIDLTSQPAHGGKTEQGLSPKSKPFATDNGAMPHKLEKADLLKAIQKQLIANVHSNDGYFEVIDFASDATITDRNGKVYFADKDGSVTLPTQPVQEFLLKGHVRVRPYKEKPVQNQAKSVDVEYTVQFTPLNPDDDFRPGLKDTKLLKTLAIGDTITSQELLAQAQSILNKTHPGYTIYERDSSIVTHDNDIFRTILPMDQEFTYHVKNREQAYEINPKTGIKEKTNNTDLVSEKYYVLKQGEKPYDPFDRSHLKLFTIKYVDVNTNELLKSEQLLTASERNLDFRDLYDPRDKAKLLYNNLDAFDIMDYTLTGKVEDNHDKNNRVVTVYMGKRPKGAKGSYHLAYDKDLYTEEERKAYSYLRDTGTPIPDNPKDK
  
Inhibitor
Name:
BDBM54873
Synonyms:
4-(2,6-dichlorophenyl)sulfanyl-6-(methoxymethyl)-2-phenylpyrimidine | 4-[(2,6-dichlorophenyl)thio]-6-(methoxymethyl)-2-phenyl-pyrimidine | 4-[(2,6-dichlorophenyl)thio]-6-(methoxymethyl)-2-phenylpyrimidine | 4-[2,6-bis(chloranyl)phenyl]sulfanyl-6-(methoxymethyl)-2-phenyl-pyrimidine | BRD-K39862507-001-04-3 | cid_1476689
Type:
Small organic molecule
Emp. Form.:
C18H14Cl2N2OS
Mol. Mass.:
377.288
SMILES:
COCc1cc(Sc2c(Cl)cccc2Cl)nc(n1)-c1ccccc1
Structure:
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