Reaction Details Report a problem with these data
Target
Tumor necrosis factor
Ligand
BDBM37212
Substrate
n/a
Meas. Tech.
HTS dose response assay for identification of inhibitors of TNFa-specific NF-kB induction
IC50
783.25±934 nM
Citation
 PubChem, PC HTS dose response assay for identification of inhibitors of TNFa-specific NF-kB induction PubChem Bioassay (2010)[AID] 
Target
Name:
Tumor necrosis factor
Synonyms:
Cachectin | TNF | TNF-a | TNF-alpha | TNFA | TNFA_HUMAN | TNFSF2 | Tumor necrosis factor (TNF-alpha) | Tumor necrosis factor (TNFa) | Tumor necrosis factor alpha (TNFα) | Tumor necrosis factor ligand superfamily member 2 | Tumor necrosis factor, membrane form | Tumor necrosis factor, soluble form | tumor necrosis factor alpha
Type:
Enzyme
Mol. Mass.:
25645.11
Organism:
Homo sapiens (Human)
Description:
P01375
Residue:
233
Sequence:
MSTESMIRDVELAEEALPKKTGGPQGSRRCLFLSLFSFLIVAGATTLFCLLHFGVIGPQREEFPRDLSLISPLAQAVRSSSRTPSDKPVAHVVANPQAEGQLQWLNRRANALLANGVELRDNQLVVPSEGLYLIYSQVLFKGQGCPSTHVLLTHTISRIAVSYQTKVNLLSAIKSPCQRETPEGAEAKPWYEPIYLGGVFQLEKGDRLSAEINRPDYLDFAESGQVYFGIIAL
  
Inhibitor
Name:
BDBM37212
Synonyms:
MLS000100814 | N-cyclohexyl-N-methyl-1-(3-methylphenyl)-4-pyrazolo[3,4-d]pyrimidinamine | N-cyclohexyl-N-methyl-1-(3-methylphenyl)pyrazolo[3,4-d]pyrimidin-4-amine | SMR000017481 | cid_866501 | cyclohexyl-methyl-[1-(m-tolyl)pyrazolo[3,4-d]pyrimidin-4-yl]amine
Type:
Small organic molecule
Emp. Form.:
C19H23N5
Mol. Mass.:
321.4194
SMILES:
CN(C1CCCCC1)c1ncnc2n(ncc12)-c1cccc(C)c1
Structure:
Search PDB for entries with ligand similarity: