Reaction Details Report a problem with these data
Target
Tumor necrosis factor
Ligand
BDBM54330
Substrate
n/a
Meas. Tech.
HTS dose response assay for identification of inhibitors of TNFa-specific NF-kB induction
IC50
1207±216.5 nM
Citation
 PubChem, PC HTS dose response assay for identification of inhibitors of TNFa-specific NF-kB induction PubChem Bioassay (2010)[AID] 
Target
Name:
Tumor necrosis factor
Synonyms:
Cachectin | TNF | TNF-a | TNF-alpha | TNFA | TNFA_HUMAN | TNFSF2 | Tumor necrosis factor (TNF-alpha) | Tumor necrosis factor (TNFa) | Tumor necrosis factor alpha (TNFα) | Tumor necrosis factor ligand superfamily member 2 | Tumor necrosis factor, membrane form | Tumor necrosis factor, soluble form | tumor necrosis factor alpha
Type:
Enzyme
Mol. Mass.:
25645.11
Organism:
Homo sapiens (Human)
Description:
P01375
Residue:
233
Sequence:
MSTESMIRDVELAEEALPKKTGGPQGSRRCLFLSLFSFLIVAGATTLFCLLHFGVIGPQREEFPRDLSLISPLAQAVRSSSRTPSDKPVAHVVANPQAEGQLQWLNRRANALLANGVELRDNQLVVPSEGLYLIYSQVLFKGQGCPSTHVLLTHTISRIAVSYQTKVNLLSAIKSPCQRETPEGAEAKPWYEPIYLGGVFQLEKGDRLSAEINRPDYLDFAESGQVYFGIIAL
  
Inhibitor
Name:
BDBM54330
Synonyms:
1,3-dibenzyl-2-(4-methoxyphenyl)benzimidazol-3-ium;bromide | 2-(4-methoxyphenyl)-1,3-bis(phenylmethyl)benzimidazol-3-ium;bromide | MLS000688421 | SMR000284327 | cid_16192864
Type:
Small organic molecule
Emp. Form.:
C28H25N2O
Mol. Mass.:
405.5104
SMILES:
COc1ccc(cc1)-c1n(Cc2ccccc2)c2ccccc2[n+]1Cc1ccccc1
Structure:
Search PDB for entries with ligand similarity: