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Target
Heat shock factor protein 1
Ligand
BDBM72256
Substrate
n/a
Meas. Tech.
Luminescence Cell-Based Dose Retest to Identify Potentiators of Heat Shock Factor 1 (HSF1)
EC50
>260000±n/a nM
Citation
 PubChem, PC Luminescence Cell-Based Dose Retest to Identify Potentiators of Heat Shock Factor 1 (HSF1) PubChem Bioassay (2010)[AID] 
Target
Name:
Heat shock factor protein 1
Synonyms:
HSF1_MOUSE | Hsf1 | Hsf1 protein
Type:
Enzyme Catalytic Domain
Mol. Mass.:
57208.68
Organism:
Mus musculus
Description:
P38532
Residue:
525
Sequence:
MDLAVGPGAAGPSNVPAFLTKLWTLVSDPDTDALICWSPSGNSFHVFDQGQFAKEVLPKYFKHNNMASFVRQLNMYGFRKVVHIEQGGLVKPERDDTEFQHPCFLRGQEQLLENIKRKVTSVSTLKSEDIKIRQDSVTRLLTDVQLMKGKQECMDSKLLAMKHENEALWREVASLRQKHAQQQKVVNKLIQFLISLVQSNRILGVKRKIPLMLSDSNSAHSVPKYGRQYSLEHVHGPGPYSAPSPAYSSSSLYSSDAVTSSGPIISDITELAPTSPLASPGRSIDERPLSSSTLVRVKQEPPSPPHSPRVLEASPGRPSSMDTPLSPTAFIDSILRESEPTPAASNTAPMDTTGAQAPALPTPSTPEKCLSVACLDKNELSDHLDAMDSNLDNLQTMLTSHGFSVDTSALLDLFSPSVTMPDMSLPDLDSSLASIQELLSPQEPPRPIEAENSNPDSGKQLVHYTAQPLFLLDPDAVDTGSSELPVLFELGESSYFSEGDDYTDDPTISLLTGTEPHKAKDPTVS
  
Inhibitor
Name:
BDBM72256
Synonyms:
2-(1,3-benzoxazol-2-yl)-2-(5-chloranyl-3-nitro-6-oxidanylidene-1-propyl-pyridazin-4-yl)ethanenitrile | 2-(1,3-benzoxazol-2-yl)-2-(5-chloro-3-nitro-6-oxo-1-propyl-4-pyridazinyl)acetonitrile | 2-(1,3-benzoxazol-2-yl)-2-(5-chloro-3-nitro-6-oxo-1-propylpyridazin-4-yl)acetonitrile | 2-(1,3-benzoxazol-2-yl)-2-(5-chloro-6-keto-3-nitro-1-propyl-pyridazin-4-yl)acetonitrile | MLS000390829 | SMR000259867 | cid_3525489
Type:
Small organic molecule
Emp. Form.:
C16H12ClN5O4
Mol. Mass.:
373.751
SMILES:
CCCn1nc(c(C(C#N)c2nc3ccccc3o2)c(Cl)c1=O)[N+]([O-])=O
Structure:
Search PDB for entries with ligand similarity: