Reaction Details Report a problem with these data
Target
Heat shock factor protein 1
Ligand
BDBM72259
Substrate
n/a
Meas. Tech.
Luminescence Cell-Based Dose Retest to Identify Potentiators of Heat Shock Factor 1 (HSF1)
EC50
>260000±n/a nM
Citation
 PubChem, PC Luminescence Cell-Based Dose Retest to Identify Potentiators of Heat Shock Factor 1 (HSF1) PubChem Bioassay (2010)[AID] 
Target
Name:
Heat shock factor protein 1
Synonyms:
HSF1_MOUSE | Hsf1 | Hsf1 protein
Type:
Enzyme Catalytic Domain
Mol. Mass.:
57208.68
Organism:
Mus musculus
Description:
P38532
Residue:
525
Sequence:
MDLAVGPGAAGPSNVPAFLTKLWTLVSDPDTDALICWSPSGNSFHVFDQGQFAKEVLPKYFKHNNMASFVRQLNMYGFRKVVHIEQGGLVKPERDDTEFQHPCFLRGQEQLLENIKRKVTSVSTLKSEDIKIRQDSVTRLLTDVQLMKGKQECMDSKLLAMKHENEALWREVASLRQKHAQQQKVVNKLIQFLISLVQSNRILGVKRKIPLMLSDSNSAHSVPKYGRQYSLEHVHGPGPYSAPSPAYSSSSLYSSDAVTSSGPIISDITELAPTSPLASPGRSIDERPLSSSTLVRVKQEPPSPPHSPRVLEASPGRPSSMDTPLSPTAFIDSILRESEPTPAASNTAPMDTTGAQAPALPTPSTPEKCLSVACLDKNELSDHLDAMDSNLDNLQTMLTSHGFSVDTSALLDLFSPSVTMPDMSLPDLDSSLASIQELLSPQEPPRPIEAENSNPDSGKQLVHYTAQPLFLLDPDAVDTGSSELPVLFELGESSYFSEGDDYTDDPTISLLTGTEPHKAKDPTVS
  
Inhibitor
Name:
BDBM72259
Synonyms:
1-(1,5-dimethylhexyl)-3-[5-(dimethylsulfamoyl)-2-methyl-phenyl]thiourea | 1-[5-(dimethylsulfamoyl)-2-methyl-phenyl]-3-(6-methylheptan-2-yl)thiourea | 1-[5-(dimethylsulfamoyl)-2-methylphenyl]-3-(6-methylheptan-2-yl)thiourea | MLS000417318 | SMR000242500 | cid_4423761
Type:
Small organic molecule
Emp. Form.:
C18H31N3O2S2
Mol. Mass.:
385.588
SMILES:
CC(C)CCCC(C)NC(=S)Nc1cc(ccc1C)S(=O)(=O)N(C)C
Structure:
Search PDB for entries with ligand similarity: