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Target
Heat shock factor protein 1
Ligand
BDBM72262
Substrate
n/a
Meas. Tech.
Luminescence Cell-Based Dose Retest to Identify Potentiators of Heat Shock Factor 1 (HSF1)
EC50
>260000±n/a nM
Citation
 PubChem, PC Luminescence Cell-Based Dose Retest to Identify Potentiators of Heat Shock Factor 1 (HSF1) PubChem Bioassay (2010)[AID] 
Target
Name:
Heat shock factor protein 1
Synonyms:
HSF1_MOUSE | Hsf1 | Hsf1 protein
Type:
Enzyme Catalytic Domain
Mol. Mass.:
57208.68
Organism:
Mus musculus
Description:
P38532
Residue:
525
Sequence:
MDLAVGPGAAGPSNVPAFLTKLWTLVSDPDTDALICWSPSGNSFHVFDQGQFAKEVLPKYFKHNNMASFVRQLNMYGFRKVVHIEQGGLVKPERDDTEFQHPCFLRGQEQLLENIKRKVTSVSTLKSEDIKIRQDSVTRLLTDVQLMKGKQECMDSKLLAMKHENEALWREVASLRQKHAQQQKVVNKLIQFLISLVQSNRILGVKRKIPLMLSDSNSAHSVPKYGRQYSLEHVHGPGPYSAPSPAYSSSSLYSSDAVTSSGPIISDITELAPTSPLASPGRSIDERPLSSSTLVRVKQEPPSPPHSPRVLEASPGRPSSMDTPLSPTAFIDSILRESEPTPAASNTAPMDTTGAQAPALPTPSTPEKCLSVACLDKNELSDHLDAMDSNLDNLQTMLTSHGFSVDTSALLDLFSPSVTMPDMSLPDLDSSLASIQELLSPQEPPRPIEAENSNPDSGKQLVHYTAQPLFLLDPDAVDTGSSELPVLFELGESSYFSEGDDYTDDPTISLLTGTEPHKAKDPTVS
  
Inhibitor
Name:
BDBM72262
Synonyms:
5-[2-(4-cyanobenzyl)oxy-5-methyl-benzoyl]-1-cyclopropyl-2-keto-nicotinonitrile | 5-[2-[(4-cyanophenyl)methoxy]-5-methyl-phenyl]carbonyl-1-cyclopropyl-2-oxidanylidene-pyridine-3-carbonitrile | 5-[2-[(4-cyanophenyl)methoxy]-5-methylbenzoyl]-1-cyclopropyl-2-oxopyridine-3-carbonitrile | 5-[[2-[(4-cyanophenyl)methoxy]-5-methylphenyl]-oxomethyl]-1-cyclopropyl-2-oxo-3-pyridinecarbonitrile | MLS000391234 | SMR000260271 | cid_2439944
Type:
Small organic molecule
Emp. Form.:
C25H19N3O3
Mol. Mass.:
409.4367
SMILES:
Cc1ccc(OCc2ccc(cc2)C#N)c(c1)C(=O)c1cc(C#N)c(=O)n(c1)C1CC1
Structure:
Search PDB for entries with ligand similarity: