Reaction Details Report a problem with these data
Target
Heat shock factor protein 1
Ligand
BDBM72270
Substrate
n/a
Meas. Tech.
Luminescence Cell-Based Dose Retest to Identify Potentiators of Heat Shock Factor 1 (HSF1)
EC50
6525±n/a nM
Citation
 PubChem, PC Luminescence Cell-Based Dose Retest to Identify Potentiators of Heat Shock Factor 1 (HSF1) PubChem Bioassay (2010)[AID] 
Target
Name:
Heat shock factor protein 1
Synonyms:
HSF1_MOUSE | Hsf1 | Hsf1 protein
Type:
Enzyme Catalytic Domain
Mol. Mass.:
57208.68
Organism:
Mus musculus
Description:
P38532
Residue:
525
Sequence:
MDLAVGPGAAGPSNVPAFLTKLWTLVSDPDTDALICWSPSGNSFHVFDQGQFAKEVLPKYFKHNNMASFVRQLNMYGFRKVVHIEQGGLVKPERDDTEFQHPCFLRGQEQLLENIKRKVTSVSTLKSEDIKIRQDSVTRLLTDVQLMKGKQECMDSKLLAMKHENEALWREVASLRQKHAQQQKVVNKLIQFLISLVQSNRILGVKRKIPLMLSDSNSAHSVPKYGRQYSLEHVHGPGPYSAPSPAYSSSSLYSSDAVTSSGPIISDITELAPTSPLASPGRSIDERPLSSSTLVRVKQEPPSPPHSPRVLEASPGRPSSMDTPLSPTAFIDSILRESEPTPAASNTAPMDTTGAQAPALPTPSTPEKCLSVACLDKNELSDHLDAMDSNLDNLQTMLTSHGFSVDTSALLDLFSPSVTMPDMSLPDLDSSLASIQELLSPQEPPRPIEAENSNPDSGKQLVHYTAQPLFLLDPDAVDTGSSELPVLFELGESSYFSEGDDYTDDPTISLLTGTEPHKAKDPTVS
  
Inhibitor
Name:
BDBM72270
Synonyms:
(E)-2-butenedioic acid bis[2-(3-chloro-4-methoxyanilino)-2-oxoethyl] ester | (E)-but-2-enedioic acid bis[2-(3-chloro-4-methoxy-anilino)-2-keto-ethyl] ester | MLS000416385 | SMR000264204 | bis[2-(3-chloro-4-methoxyanilino)-2-oxoethyl] (E)-but-2-enedioate | bis[2-[(3-chloranyl-4-methoxy-phenyl)amino]-2-oxidanylidene-ethyl] (E)-but-2-enedioate | cid_5823841
Type:
Small organic molecule
Emp. Form.:
C22H20Cl2N2O8
Mol. Mass.:
511.309
SMILES:
COc1ccc(NC(=O)COC(=O)\C=C\C(=O)OCC(=O)Nc2ccc(OC)c(Cl)c2)cc1Cl
Structure:
Search PDB for entries with ligand similarity: