Reaction Details Report a problem with these data
Target
Heat shock factor protein 1
Ligand
BDBM72275
Substrate
n/a
Meas. Tech.
Luminescence Cell-Based Dose Retest to Identify Potentiators of Heat Shock Factor 1 (HSF1)
EC50
13400±n/a nM
Citation
 PubChem, PC Luminescence Cell-Based Dose Retest to Identify Potentiators of Heat Shock Factor 1 (HSF1) PubChem Bioassay (2010)[AID] 
Target
Name:
Heat shock factor protein 1
Synonyms:
HSF1_MOUSE | Hsf1 | Hsf1 protein
Type:
Enzyme Catalytic Domain
Mol. Mass.:
57208.68
Organism:
Mus musculus
Description:
P38532
Residue:
525
Sequence:
MDLAVGPGAAGPSNVPAFLTKLWTLVSDPDTDALICWSPSGNSFHVFDQGQFAKEVLPKYFKHNNMASFVRQLNMYGFRKVVHIEQGGLVKPERDDTEFQHPCFLRGQEQLLENIKRKVTSVSTLKSEDIKIRQDSVTRLLTDVQLMKGKQECMDSKLLAMKHENEALWREVASLRQKHAQQQKVVNKLIQFLISLVQSNRILGVKRKIPLMLSDSNSAHSVPKYGRQYSLEHVHGPGPYSAPSPAYSSSSLYSSDAVTSSGPIISDITELAPTSPLASPGRSIDERPLSSSTLVRVKQEPPSPPHSPRVLEASPGRPSSMDTPLSPTAFIDSILRESEPTPAASNTAPMDTTGAQAPALPTPSTPEKCLSVACLDKNELSDHLDAMDSNLDNLQTMLTSHGFSVDTSALLDLFSPSVTMPDMSLPDLDSSLASIQELLSPQEPPRPIEAENSNPDSGKQLVHYTAQPLFLLDPDAVDTGSSELPVLFELGESSYFSEGDDYTDDPTISLLTGTEPHKAKDPTVS
  
Inhibitor
Name:
BDBM72275
Synonyms:
(E)-2-butenedioic acid O4-[2-[(diphenylmethyl)amino]-2-oxoethyl] ester O1-ethyl ester | (E)-but-2-enedioic acid O4-[2-(benzhydrylamino)-2-keto-ethyl] ester O1-ethyl ester | 4-O-[2-(benzhydrylamino)-2-oxoethyl] 1-O-ethyl (E)-but-2-enedioate | MLS000374880 | O4-[2-[(diphenylmethyl)amino]-2-oxidanylidene-ethyl] O1-ethyl (E)-but-2-enedioate | SMR000254234 | cid_5889878
Type:
Small organic molecule
Emp. Form.:
C21H21NO5
Mol. Mass.:
367.3951
SMILES:
CCOC(=O)\C=C\C(=O)OCC(=O)NC(c1ccccc1)c1ccccc1
Structure:
Search PDB for entries with ligand similarity: