Reaction Details Report a problem with these data
Target
Eukaryotic translation initiation factor 4H
Ligand
BDBM61356
Substrate
n/a
Meas. Tech.
SAR analysis for the identification of translation initiation inhibitors (eIF4H)
IC50
27550±n/a nM
Citation
 PubChem, PC SAR analysis for the identification of translation initiation inhibitors (eIF4H) PubChem Bioassay (2010)[AID] 
Target
Name:
Eukaryotic translation initiation factor 4H
Synonyms:
EIF4H | IF4H_HUMAN | KIAA0038 | WBSCR1 | WSCR1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
27385.24
Organism:
Homo sapiens (Human)
Description:
Q15056
Residue:
248
Sequence:
MADFDTYDDRAYSSFGGGRGSRGSAGGHGSRSQKELPTEPPYTAYVGNLPFNTVQGDIDAIFKDLSIRSVRLVRDKDTDKFKGFCYVEFDEVDSLKEALTYDGALLGDRSLRVDIAEGRKQDKGGFGFRKGGPDDRGMGSSRESRGGWDSRDDFNSGFRDDFLGGRGGSRPGDRRTGPPMGSRFRDGPPLRGSNMDFREPTEEERAQRPRLQLKPRTVATPLNQVANPNSAIFGGARPREEVVQKEQE
  
Inhibitor
Name:
BDBM61356
Synonyms:
2-(4-naphthalen-2-ylsulfonylpiperazin-1-yl)-N-propan-2-yl-propanamide | 2-(4-naphthalen-2-ylsulfonylpiperazin-1-yl)-N-propan-2-ylpropanamide | 2-[4-(2-naphthalenylsulfonyl)-1-piperazinyl]-N-propan-2-ylpropanamide | MLS001173979 | N-isopropyl-2-[4-(2-naphthylsulfonyl)piperazino]propionamide | SMR000591247 | cid_16283830
Type:
Small organic molecule
Emp. Form.:
C20H27N3O3S
Mol. Mass.:
389.512
SMILES:
CC(C)NC(=O)C(C)N1CCN(CC1)S(=O)(=O)c1ccc2ccccc2c1
Structure:
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