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Target
Melanin-concentrating hormone receptor 1
Ligand
BDBM75876
Substrate
n/a
Meas. Tech.
Late-stage fluorescence-based counterscreen for antagonists of the G-protein coupled receptor 7 (GPR7)
IC50
5000±n/a nM
Citation
 PubChem, PC Late-stage fluorescence-based counterscreen for antagonists of the G-protein coupled receptor 7 (GPR7): cell-based dose response assay to identify antagonists of the melanin-concentrating hormone receptor 1 (MCHR1) PubChem Bioassay (2010)[AID] 
Target
Name:
Melanin-concentrating hormone receptor 1
Synonyms:
G-protein coupled receptor 24 | GPR24 | MCH receptor 1 | MCH-1R | MCH-R1 | MCHR | MCHR-1 | MCHR1 | MCHR1_HUMAN | Melanin Concentrating Hormone 1 | Melanin-Concentrating Hormone Receptor 1 (MCH1R) | Melanin-concentrating hormone receptor | Melanin-concentrating hormone receptor 1 (MCH-1) | Melanin-concentrating hormone receptor 1 (MCH1) | Melanin-concentrating hormone receptor 1 (MCHR-1) | Melanin-concentrating hormone receptor 1 (MCHR1) | SLC-1 | SLC1 | Somatostatin receptor-like protein
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
45976.27
Organism:
Homo sapiens (Human)
Description:
Membranes from CHO-K1 cells stably expressing human MCH1R were used in assays.
Residue:
422
Sequence:
MSVGAMKKGVGRAVGLGGGSGCQATEEDPLPNCGACAPGQGGRRWRLPQPAWVEGSSARLWEQATGTGWMDLEASLLPTGPNASNTSDGPDNLTSAGSPPRTGSISYINIIMPSVFGTICLLGIIGNSTVIFAVVKKSKLHWCNNVPDIFIINLSVVDLLFLLGMPFMIHQLMGNGVWHFGETMCTLITAMDANSQFTSTYILTAMAIDRYLATVHPISSTKFRKPSVATLVICLLWALSFISITPVWLYARLIPFPGGAVGCGIRLPNPDTDLYWFTLYQFFLAFALPFVVITAAYVRILQRMTSSVAPASQRSIRLRTKRVTRTAIAICLVFFVCWAPYYVLQLTQLSISRPTLTFVYLYNAAISLGYANSCLNPFVYIVLCETFRKRLVLSVKPAAQGQLRAVSNAQTADEERTESKGT
  
Inhibitor
Name:
BDBM75876
Synonyms:
4-[5-chloro-3-keto-2-(p-tolyl)pyridazin-4-yl]oxypiperidine-1-carboxylic acid tert-butyl ester | 4-[[5-chloro-2-(4-methylphenyl)-3-oxo-4-pyridazinyl]oxy]-1-piperidinecarboxylic acid tert-butyl ester | SR-02000000342 | SR-02000000342-1 | cid_45382322 | tert-butyl 4-[5-chloranyl-2-(4-methylphenyl)-3-oxidanylidene-pyridazin-4-yl]oxypiperidine-1-carboxylate | tert-butyl 4-[5-chloro-2-(4-methylphenyl)-3-oxopyridazin-4-yl]oxypiperidine-1-carboxylate
Type:
Small organic molecule
Emp. Form.:
C21H26ClN3O4
Mol. Mass.:
419.902
SMILES:
Cc1ccc(cc1)-n1ncc(Cl)c(OC2CCN(CC2)C(=O)OC(C)(C)C)c1=O
Structure:
Search PDB for entries with ligand similarity: