Reaction Details Report a problem with these data
Target
Delta-type opioid receptor
Ligand
BDBM75572
Substrate
n/a
Meas. Tech.
SAR Analysis of Antagonists of the DOR Receptor using an Image-Based Assay - Set 3
IC50
31300±n/a nM
Citation
 PubChem, PC SAR Analysis of Antagonists of the DOR Receptor using an Image-Based Assay - Set 3 PubChem Bioassay (2010)[AID] 
Target
Name:
Delta-type opioid receptor
Synonyms:
D-OR-1 | DOR-1 | Delta opioid receptor | Delta-type opioid receptor (Delta) | OPIATE Delta | OPRD | OPRD1 | OPRD_HUMAN | OPRK1 | opioid receptor, delta 1
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
40382.98
Organism:
Homo sapiens (Human)
Description:
Competition binding assays were carried out using membrane preparations from transfected HN9.10 cells that constitutively expressed the delta opioid receptor.
Residue:
372
Sequence:
MEPAPSAGAELQPPLFANASDAYPSACPSAGANASGPPGARSASSLALAIAITALYSAVCAVGLLGNVLVMFGIVRYTKMKTATNIYIFNLALADALATSTLPFQSAKYLMETWPFGELLCKAVLSIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPAKAKLINICIWVLASGVGVPIMVMAVTRPRDGAVVCMLQFPSPSWYWDTVTKICVFLFAFVVPILIITVCYGLMLLRLRSVRLLSGSKEKDRSLRRITRMVLVVVGAFVVCWAPIHIFVIVWTLVDIDRRDPLVVAALHLCIALGYANSSLNPVLYAFLDENFKRCFRQLCRKPCGRPDPSSFSRAREATARERVTACTPSDGPGGGAAA
  
Inhibitor
Name:
BDBM75572
Synonyms:
4-[(2-naphthalenylsulfonylamino)methyl]-N-[2-[(phenylmethyl)-propan-2-ylamino]ethyl]benzamide | 4-[(naphthalen-2-ylsulfonylamino)methyl]-N-[2-[(phenylmethyl)-propan-2-yl-amino]ethyl]benzamide | KSC-11-130-1 | KUC105398N | N-[2-[benzyl(isopropyl)amino]ethyl]-4-[(2-naphthylsulfonylamino)methyl]benzamide | N-[2-[benzyl(propan-2-yl)amino]ethyl]-4-[(naphthalen-2-ylsulfonylamino)methyl]benzamide | cid_45115585
Type:
Small organic molecule
Emp. Form.:
C30H33N3O3S
Mol. Mass.:
515.666
SMILES:
CC(C)N(CCNC(=O)c1ccc(CNS(=O)(=O)c2ccc3ccccc3c2)cc1)Cc1ccccc1
Structure:
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