Reaction Details Report a problem with these data
Target
Mitochondrial import inner membrane translocase subunit TIM10
Ligand
BDBM77920
Substrate
n/a
Meas. Tech.
Dose Response confirmation of uHTS small molecule inhibitors of tim23-1: a luminescent tim10-1 yeast counterscreen.
IC50
>100000±n/a nM
Citation
 PubChem, PC Dose Response confirmation of uHTS small molecule inhibitors of tim23-1: a luminescent tim10-1 yeast counterscreen. PubChem Bioassay (2011)[AID] 
Target
Name:
Mitochondrial import inner membrane translocase subunit TIM10
Synonyms:
MRS11 | TIM10 | TIM10_YEAST | TPA: Essential protein of the mitochondrial intermembrane space | TPA: Essential protein of the mitochondrial intermembrane space, forms a complex with Tim9p (TIM10 complex) that delivers hydrophobic proteins to the TIM22 complex for insertion into the inner ...
Type:
Enzyme Catalytic Domain
Mol. Mass.:
10303.50
Organism:
Baker's yeast
Description:
gi_285809906
Residue:
93
Sequence:
MSFLGFGGGQPQLSSQQKIQAAEAELDLVTDMFNKLVNNCYKKCINTSYSEGELNKNESSCLDRCVAKYFETNVQVGENMQKMGQSFNAAGKF
  
Inhibitor
Name:
BDBM77920
Synonyms:
4-[[2-[(4-keto-9-methyl-pyrido[1,2-a][1,3,5]triazin-2-yl)thio]acetyl]amino]benzoic acid ethyl ester | 4-[[2-[(9-methyl-4-oxo-2-pyrido[1,2-a][1,3,5]triazinyl)thio]-1-oxoethyl]amino]benzoic acid ethyl ester | MLS001234980 | SMR000810974 | cid_7259312 | ethyl 4-[2-(9-methyl-4-oxidanylidene-pyrido[1,2-a][1,3,5]triazin-2-yl)sulfanylethanoylamino]benzoate | ethyl 4-[[2-(9-methyl-4-oxopyrido[1,2-a][1,3,5]triazin-2-yl)sulfanylacetyl]amino]benzoate
Type:
Small organic molecule
Emp. Form.:
C19H18N4O4S
Mol. Mass.:
398.436
SMILES:
CCOC(=O)c1ccc(NC(=O)CSc2nc3c(C)cccn3c(=O)n2)cc1
Structure:
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