Reaction Details
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DNA dC->dU-editing enzyme APOBEC-3A
Ligand
BDBM61634
Substrate
n/a
Meas. Tech.
Dose Response confirmation of small molecule APOBEC3A DNA Deaminase Inhibitors via a fluorescence-based single-stranded DNA deaminase assay
Temperature
298.15±n/a K
IC50
>100000±n/a nM
Comments
extracted
Citation
PubChem, PC Dose Response confirmation of small molecule APOBEC3A DNA Deaminase Inhibitors via a fluorescence-based single-stranded DNA deaminase assay PubChem Bioassay (2011)[AID] More Info.:
Target
Name:
DNA dC->dU-editing enzyme APOBEC-3A
Synonyms:
ABC3A_HUMAN | APOBEC3A | probable DNA dC->dU-editing enzyme APOBEC-3A
Type:
Enzyme Catalytic Domain
Mol. Mass.:
23013.77
Organism:
Homo sapiens (Human)
Description:
gi_21955158
Residue:
199
Sequence:
MEASPASGPRHLMDPHIFTSNFNNGIGRHKTYLCYEVERLDNGTSVKMDQHRGFLHNQAKNLLCGFYGRHAELRFLDLVPSLQLDPAQIYRVTWFISWSPCFSWGCAGEVRAFLQENTHVRLRIFAARIYDYDPLYKEALQMLRDAGAQVSIMTYDEFKHCWDTFVDHQGCPFQPWDGLDEHSQALSGRLRAILQNQGN
Inhibitor
Name:
BDBM61634
Synonyms:
1-allyl-2-methyl-3-[(E)-2-(1-methylpyridin-1-ium-4-yl)vinyl]indole;iodide | 2-methyl-3-[(E)-2-(1-methyl-4-pyridin-1-iumyl)ethenyl]-1-prop-2-enylindole;iodide | 2-methyl-3-[(E)-2-(1-methylpyridin-1-ium-4-yl)ethenyl]-1-prop-2-enyl-indole;iodide | 2-methyl-3-[(E)-2-(1-methylpyridin-1-ium-4-yl)ethenyl]-1-prop-2-enylindole;iodide | 4-[(E)-2-(1-Allyl-2-methyl-1H-indol-3-yl)-vinyl]-1-methyl-pyridinium | MLS001210236 | SMR000504344 | cid_23724408
Type:
Small organic molecule
Emp. Form.:
C20H21N2
Mol. Mass.:
289.3936
SMILES:
Cc1c(\C=C\c2cc[n+](C)cc2)c2ccccc2n1CC=C
Structure:
