Reaction Details Report a problem with these data
Target
Free fatty acid receptor 2
Ligand
BDBM271079
Substrate
n/a
Meas. Tech.
Ca-Flux Functional Assay
EC50
25.0±n/a nM
Citation
 Barker, G; Davenport, R; Downham, R; Farnaby, W; Goldby, A; Hannah, D; Harrison, D; Willems, H 3-substituted 2-amino-indole derivatives US Patent  US10059713 Publication Date 8/28/2018 
Target
Name:
Free fatty acid receptor 2
Synonyms:
FFA2 | FFAR2 | FFAR2_HUMAN | G-protein coupled receptor 43 | GPCR43 | GPR43
Type:
PROTEIN
Mol. Mass.:
37156.44
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1508993
Residue:
330
Sequence:
MLPDWKSSLILMAYIIIFLTGLPANLLALRAFVGRIRQPQPAPVHILLLSLTLADLLLLLLLPFKIIEAASNFRWYLPKVVCALTSFGFYSSIYCSTWLLAGISIERYLGVAFPVQYKLSRRPLYGVIAALVAWVMSFGHCTIVIIVQYLNTTEQVRSGNEITCYENFTDNQLDVVLPVRLELCLVLFFIPMAVTIFCYWRFVWIMLSQPLVGAQRRRRAVGLAVVTLLNFLVCFGPYNVSHLVGYHQRKSPWWRSIAVVFSSLNASLDPLLFYFSSSVVRRAFGRGLQVLRNQGSSLLGRRGKDTAEGTNEDRGVGQGEGMPSSDFTTE
  
Inhibitor
Name:
BDBM271079
Synonyms:
4-[(2R,6R)-2,6-dimethylmorpholin-4-yl]-7-(3-fluorobenzenesulfonyl)-2-methyl-5H-pyrrolo[3,2-d]pyrimidin-6-amine | US10059713, Example 200
Type:
Small organic molecule
Emp. Form.:
C19H22FN5O3S
Mol. Mass.:
419.473
SMILES:
C[C@@H]1CN(C[C@@H](C)O1)c1nc(C)nc2c(c(N)[nH]c12)S(=O)(=O)c1cccc(F)c1 |r|
Structure:
Search PDB for entries with ligand similarity: