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Target
Alpha-1A adrenergic receptor
Ligand
BDBM50245652
Substrate
n/a
Meas. Tech.
ChEMBL_1675493 (CHEMBL4025636)
Ki
0.180000±n/a nM
Citation
 Kaur, R; Chaudhary, S; Kumar, K; Gupta, MK; Rawal, RK Recent synthetic and medicinal perspectives of dihydropyrimidinones: A review. Eur J Med Chem 132:108-134 (2017) [PubMed]  Article 
Target
Name:
Alpha-1A adrenergic receptor
Synonyms:
ADA1A_HUMAN | ADRA1A | ADRA1C | Adrenergic alpha1A | Alpha 1A-adrenoceptor | Alpha 1A-adrenoreceptor | Alpha adrenergic receptor 1a | Alpha-1C adrenergic receptor | Alpha-adrenergic receptor 1c | Cerebral cortex alpha adrenergic receptor | adrenergic Alpha1 | adrenergic Alpha1C
Type:
Cell-surface receptors
Mol. Mass.:
51511.67
Organism:
Homo sapiens (Human)
Description:
P35348
Residue:
466
Sequence:
MVFLSGNASDSSNCTQPPAPVNISKAILLGVILGGLILFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVLPFSAIFEVLGYWAFGRVFCNIWAAVDVLCCTASIMGLCIISIDRYIGVSYPLRYPTIVTQRRGLMALLCVWALSLVISIGPLFGWRQPAPEDETICQINEEPGYVLFSALGSFYLPLAIILVMYCRVYVVAKRESRGLKSGLKTDKSDSEQVTLRIHRKNAPAGGSGMASAKTKTHFSVRLLKFSREKKAAKTLGIVVGCFVLCWLPFFLVMPIGSFFPDFKPSETVFKIVFWLGYLNSCINPIIYPCSSQEFKKAFQNVLRIQCLCRKQSSKHALGYTLHPPSQAVEGQHKDMVRIPVGSRETFYRISKTDGVCEWKFFSSMPRGSARITVSKDQSSCTTARVRSKSFLQVCCCVGPSTPSLDKNHQVPTIKVHTISLSENGEEV
  
Inhibitor
Name:
BDBM50245652
Synonyms:
CHEMBL4081581
Type:
Small organic molecule
Emp. Form.:
C27H30F4N4O2
Mol. Mass.:
518.5463
SMILES:
CN1C(=O)N[C@@H](C(C(=O)NCCCN2CCC(CC2)c2ccc(F)c(F)c2)=C1C)c1ccc(F)c(F)c1 |r,c:28|
Structure:
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