Reaction Details Report a problem with these data
Target
Prostaglandin E2 receptor EP1 subtype
Ligand
BDBM50260740
Substrate
n/a
Meas. Tech.
ChEBML_1694570
IC50
8.0±n/a nM
Citation
 Nishigaya, Y; Umei, K; Saito, Y; Watanabe, H; Kondo, T; Kondo, A; Kawamura, N; Tatani, K; Kohno, Y; Tanaka, N; Seto, S Discovery of novel pyrazolo[1,5-a]pyridine-based EP Bioorg Med Chem Lett 27:4044-4050 (2017) [PubMed]  Article 
Target
Name:
Prostaglandin E2 receptor EP1 subtype
Synonyms:
PE2R1_RAT | Prostanoid EP1 receptor | Ptger1
Type:
Enzyme
Mol. Mass.:
43080.10
Organism:
Rattus norvegicus (Rat)
Description:
P70597
Residue:
405
Sequence:
MSPYGLNLSLVDEATTCVTPRVPNTSVVLPTGGNGTSPALPIFSMTLGAVSNVLALALLAQVAGRLRRRRSTATFLLFVASLLAIDLAGHVIPGALVLRLYTAGRAPAGGACHFLGGCMVFFGLCPLLLGCGMAVERCVGVTQPLIHAARVSVARARLALALLAAMALAVALLPLVHVGHYELQYPGTWCFISLGPPGGWRQALLAGLFAGLGLAALLAALVCNTLSGLALLRARWRRRRSRRFRENAGPDDRRRWGSRGLRLASASSASSITSTTAALRSSRGGGSARRVHAHDVEMVGQLVGIMVVSCICWSPLLVLVVLAIGGWNSNSLQRPLFLAVRLASWNQILDPWVYILLRQAMLRQLLRLLPLRVSAKGGPTELSLTKSAWEASSLRSSRHSGFSHL
  
Inhibitor
Name:
BDBM50260740
Synonyms:
CHEMBL4100262
Type:
Small organic molecule
Emp. Form.:
C20H14ClN3O2
Mol. Mass.:
363.797
SMILES:
OC(=O)c1cccc(Cc2c(nn3cc(Cl)ccc23)-c2ccccc2)n1
Structure:
Search PDB for entries with ligand similarity: