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Target
Metallo-beta-lactamase type 2
Ligand
BDBM50271834
Substrate
n/a
Meas. Tech.
ChEMBL_1711701 (CHEMBL4121750)
IC50
71000±n/a nM
Citation
 Zhang, D; Markoulides, MS; Stepanovs, D; Rydzik, AM; El-Hussein, A; Bon, C; Kamps, JJAG; Umland, KD; Collins, PM; Cahill, ST; Wang, DY; von Delft, F; Brem, J; McDonough, MA; Schofield, CJ Structure activity relationship studies on rhodanines and derived enethiol inhibitors of metallo-?-lactamases. Bioorg Med Chem 26:2928-2936 (2018) [PubMed]  Article 
Target
Name:
Metallo-beta-lactamase type 2
Synonyms:
BLAB_AERHY | Beta-lactamase | cphA
Type:
PROTEIN
Mol. Mass.:
28022.56
Organism:
Aeromonas hydrophila
Description:
ChEMBL_641771
Residue:
254
Sequence:
MMKGWMKCGLAGAVVLMASFWGGSVRAAGMSLTQVSGPVYVVEDNYYVQENSMVYFGAKGVTVVGATWTPDTARELHKLIKRVSRKPVLEVINTNYHTDRAGGNAYWKSIGAKVVSTRQTRDLMKSDWAEIVAFTRKGLPEYPDLPLVLPNVVHDGDFTLQEGKVRAFYAGPAHTPDGIFVYFPDEQVLYGNCILKEKLGNLSFADVKAYPQTLERLKAMKLPIKTVIGGHDSPLHGPELIDHYEALIKAAPQS
  
Inhibitor
Name:
BDBM50271834
Synonyms:
CHEMBL3234727
Type:
Small organic molecule
Emp. Form.:
C8H8O2S
Mol. Mass.:
168.213
SMILES:
OC(=O)C(S)c1ccccc1
Structure:
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