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Target
Proteasome subunit beta type-5
Ligand
BDBM50273514
Substrate
n/a
Meas. Tech.
ChEMBL_1712990 (CHEMBL4123039)
IC50
9.7±n/a nM
Citation
 Xu, Y; Yang, X; Chen, Y; Chen, H; Sun, H; Li, W; Xie, Q; Yu, L; Shao, L Discovery of novel 20S proteasome inhibitors by rational topology-based scaffold hopping of bortezomib. Bioorg Med Chem Lett 28:2148-2152 (2018) [PubMed]  Article 
Target
Name:
Proteasome subunit beta type-5
Synonyms:
20S proteasome chymotrypsin-like | 26S proteosome | LMPX | MB1 | PSB5_HUMAN | PSMB5 | Proteasome Macropain subunit MB1 | Proteasome subunit beta type-1/beta type-5 | X
Type:
Protein
Mol. Mass.:
28480.96
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
263
Sequence:
MALASVLERPLPVNQRGFFGLGGRADLLDLGPGSLSDGLSLAAPGWGVPEEPGIEMLHGTTTLAFKFRHGVIVAADSRATAGAYIASQTVKKVIEINPYLLGTMAGGAADCSFWERLLARQCRIYELRNKERISVAAASKLLANMVYQYKGMGLSMGTMICGWDKRGPGLYYVDSEGNRISGATFSVGSGSVYAYGVMDRGYSYDLEVEQAYDLARRAIYQATYRDAYSGGAVNLYHVREDGWIRVSSDNVADLHEKYSGSTP
  
Inhibitor
Name:
BDBM50273514
Synonyms:
CHEMBL4127259
Type:
Small organic molecule
Emp. Form.:
C21H29BN2O3
Mol. Mass.:
368.278
SMILES:
CC(C)C[C@H](NC(=O)[C@H](Cc1ccccc1)NCc1ccccc1)B(O)O |r|
Structure:
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