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Target
Cruzipain
Ligand
BDBM50282986
Substrate
n/a
Meas. Tech.
ChEMBL_1725283 (CHEMBL4140561)
IC50
600±n/a nM
Citation
 de Oliveira Filho, GB; Cardoso, MVO; Espíndola, JWP; Oliveira E Silva, DA; Ferreira, RS; Coelho, PL; Anjos, PSD; Santos, ES; Meira, CS; Moreira, DRM; Soares, MBP; Leite, ACL Structural design, synthesis and pharmacological evaluation of thiazoles against Trypanosoma cruzi. Eur J Med Chem 141:346-361 (2017) [PubMed]  Article 
Target
Name:
Cruzipain
Synonyms:
CYSP_TRYCR | Cruzain | Cruzaine | Major cysteine proteinase
Type:
Protein
Mol. Mass.:
49831.41
Organism:
Trypanosoma cruzi
Description:
P25779
Residue:
467
Sequence:
MSGWARALLLAAVLVVMACLVPAATASLHAEETLTSQFAEFKQKHGRVYESAAEEAFRLSVFRENLFLARLHAAANPHATFGVTPFSDLTREEFRSRYHNGAAHFAAAQERARVPVKVEVVGAPAAVDWRARGAVTAVKDQGQCGSCWAFSAIGNVECQWFLAGHPLTNLSEQMLVSCDKTDSGCSGGLMNNAFEWIVQENNGAVYTEDSYPYASGEGISPPCTTSGHTVGATITGHVELPQDEAQIAAWLAVNGPVAVAVDASSWMTYTGGVMTSCVSEQLDHGVLLVGYNDSAAVPYWIIKNSWTTQWGEEGYIRIAKGSNQCLVKEEASSAVVGGPGPTPEPTTTTTTSAPGPSPSYFVQMSCTDAACIVGCENVTLPTGQCLLTTSGVSAIVTCGAETLTEEVFLTSTHCSGPSVRSSVPLNKCNRLLRGSVEFFCGSSSSGRLADVDRQRRHQPYHSRHRRL
  
Inhibitor
Name:
BDBM50282986
Synonyms:
CHEMBL3786939
Type:
Small organic molecule
Emp. Form.:
C12H11Cl2N3S
Mol. Mass.:
300.207
SMILES:
C\C(=N/Nc1nc(C)cs1)c1ccc(Cl)c(Cl)c1
Structure:
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