Reaction Details Report a problem with these data
Target
Melanocortin receptor 4
Ligand
BDBM294016
Substrate
n/a
Meas. Tech.
ChEMBL_1749939 (CHEMBL4184699)
EC50
21±n/a nM
Citation
  TBA Bioorg Med Chem Lett 28:429-436 (2018) [PubMed]  Article 
Target
Name:
Melanocortin receptor 4
Synonyms:
MC4-R | MC4R_RAT | Mc4r
Type:
PROTEIN
Mol. Mass.:
36892.87
Organism:
Rattus norvegicus
Description:
ChEMBL_11005
Residue:
332
Sequence:
MNSTHHHGMYTSLHLWNRSSHGLHGNASESLGKGHSDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLITMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGANMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELPGRY
  
Inhibitor
Name:
BDBM294016
Synonyms:
1-(5-((4-((2S)-1-(1H-Tetrazol-5- yl)pent-3-yn-2- yl)phenoxy)methyl)benzo[b] thiophen-3-yl)-2-methylpiperidine | US10106553, Compound 48
Type:
Small organic molecule
Emp. Form.:
C27H29N5OS
Mol. Mass.:
471.617
SMILES:
CC#C[C@@H](Cc1nnn[nH]1)c1ccc(OCc2ccc3scc(N4CCCCC4C)c3c2)cc1 |r|
Structure:
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