Reaction Details Report a problem with these data
Target
GMP reductase 2
Ligand
BDBM50456083
Substrate
n/a
Meas. Tech.
ChEMBL_1755117 (CHEMBL4189877)
Ki
>5000±n/a nM
Citation
 Chacko, S; Boshoff, HIM; Singh, V; Ferraris, DM; Gollapalli, DR; Zhang, M; Lawson, AP; Pepi, MJ; Joachimiak, A; Rizzi, M; Mizrahi, V; Cuny, GD; Hedstrom, L Expanding Benzoxazole-Based Inosine 5'-Monophosphate Dehydrogenase (IMPDH) Inhibitor Structure-Activity As Potential Antituberculosis Agents. J Med Chem 61:4739-4756 (2018) [PubMed]  Article 
Target
Name:
GMP reductase 2
Synonyms:
1.7.1.7 | GMP reductase 2 | GMPR 2 | GMPR2 | GMPR2_HUMAN | Guanosine monophosphate reductase 2
Type:
PROTEIN
Mol. Mass.:
37878.01
Organism:
Homo sapiens
Description:
ChEMBL_118262
Residue:
348
Sequence:
MPHIDNDVKLDFKDVLLRPKRSTLKSRSEVDLTRSFSFRNSKQTYSGVPIIAANMDTVGTFEMAKVLCKFSLFTAVHKHYSLVQWQEFAGQNPDCLEHLAASSGTGSSDFEQLEQILEAIPQVKYICLDVANGYSEHFVEFVKDVRKRFPQHTIMAGNVVTGEMVEELILSGADIIKVGIGPGSVCTTRKKTGVGYPQLSAVMECADAAHGLKGHIISDGGCSCPGDVAKAFGAGADFVMLGGMLAGHSESGGELIERDGKKYKLFYGMSSEMAMKKYAGGVAEYRASEGKTVEVPFKGDVEHTIRDILGGIRSTCTYVGAAKLKELSRRTTFIRVTQQVNPIFSEAC
  
Inhibitor
Name:
BDBM50456083
Synonyms:
CHEMBL4213733
Type:
Small organic molecule
Emp. Form.:
C23H16Cl2N2O5
Mol. Mass.:
471.29
SMILES:
C[C@H](Oc1cccc(Cl)c1Cl)C(=O)Nc1ccc2oc(nc2c1)-c1ccc(cc1)C(O)=O |r|
Structure:
Search PDB for entries with ligand similarity: