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Target
Aldo-keto reductase family 1 member B1 [K65Q]
Ligand
BDBM50022398
Substrate
n/a
Meas. Tech.
ChEMBL_31463 (CHEMBL647985)
IC50
10000±n/a nM
Citation
 Schnur, RC; Sarges, R; Peterson, MJ Spiro oxazolidinedione aldose reductase inhibitors. J Med Chem 25:1451-4 (1983) [PubMed]  Article 
Target
Name:
Aldo-keto reductase family 1 member B1 [K65Q]
Synonyms:
AKR1B1 | ALDR_BOVIN | Aldose reductase
Type:
Protein
Mol. Mass.:
35916.27
Organism:
Bos taurus (Cattle)
Description:
P16116[K65Q]
Residue:
315
Sequence:
AHNIVLYTGAKMPILGLGTWKSPPGKVTEAVKVAIDLGYRHIDCAHVYQNENEVGLALQAKLQEQVVKREDLFIVSKLWCTYHDKDLVKGACQKTLSDLKLDYLDLYLIHWPTGFKPGKDFFPLDEDGNVIPSEKDFVDTWTAMEELVDEGLVKAIGVSNFNHLQVEKILNKPGLKYKPAVNQIECHPYLTQEKLIQYCNSKGIVVTAYSPLGSPDRPWAKPEDPSILEDPRIKAIADKYNKTTAQVLIRFPIQRNLIVIPKSVTPERIAENFQVFDFELDKEDMNTLLSYNRDWRACALVSCASHRDYPFHEEF
  
Inhibitor
Name:
BDBM50022398
Synonyms:
(+)-6-chloro-2,3-dihydro-2'H,4'H-spiro[chromene-4,5'-[1,3]oxazolidine]-2',4'-dione | (-)-6-chloro-2,3-dihydro-2'H,4'H-spiro[chromene-4,5'-[1,3]oxazolidine]-2',4'-dione | 6-chloro-2,3-dihydro-2'H,4'H-spiro[chromene-4,5'-[1,3]oxazolidine]-2',4'-dione | CHEMBL32799
Type:
Small organic molecule
Emp. Form.:
C11H8ClNO4
Mol. Mass.:
253.639
SMILES:
OC1=NC(=O)C2(CCOc3ccc(Cl)cc23)O1 |t:1|
Structure:
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