Reaction Details Report a problem with these data
Target
Type-1 angiotensin II receptor
Ligand
BDBM50035449
Substrate
n/a
Meas. Tech.
ChEMBL_36631 (CHEMBL652870)
IC50
0.210000±n/a nM
Citation
Chang, LL; Ashton, WT; Flanagan, KL; Chen, TB; O'Malley, SS; Zingaro, GJ; Siegl, PK; Kivlighn, SD; Lotti, VJ; Chang, RS Triazolinone biphenylsulfonamides as angiotensin II receptor antagonists with high affinity for both the AT1 and AT2 subtypes. J Med Chem 37:4464-78 (1995) [PubMed] Article
More Info.:
Target
Name:
Type-1 angiotensin II receptor
Synonyms:
AGTR1 | AGTR1_RABIT | ANGIOTENSIN AT1 | Angiotensin II receptor | Angiotensin II type 1a (AT-1a) receptor
Type:
Enzyme Catalytic Domain
Mol. Mass.:
41009.15
Organism:
RABBIT
Description:
ANGIOTENSIN AT1 AGTR1 RABBIT::P34976
Residue:
359
Sequence:
MMLNSSTEDGIKRIQDDCPKAGRHNYIFVMIPTLYSIIFVVGIFGNSLAVIVIYFYMKLKTVASVFLLNLALADLCFLLTLPLWAVYTAMEYRWPFGNYLCKIASASVSFNLYASVFLLTCLSIDRYLAIVHPMKSRLRRTMLVAKVTCIIIWLLAGLASLPAIIHRNVFFIENTNITVCAFHYESQNSTLPIGLGLTKNILGFLFPFLIILTSYTLIWKALKKAYEIQKNKPRNDDIFKIIMAIVLFFFFSWVPHQIFTFLDVLIQLGVIHDCRIADIVDTAMPITICIAYFNNCLNPLFYGFLGKKFKKYFLQLLKYIPPKAKSHSNLSTKMSTLSYRPSDNVSSSSKKPVPCFEVE
Inhibitor
Name:
BDBM50035449
Synonyms:
CHEMBL275552 | N-(3-{3-Butyl-4-[2'-(2-chloro-benzoylsulfamoyl)-biphenyl-4-ylmethyl]-5-oxo-4,5-dihydro-[1,2,4]triazol-1-yl}-4-trifluoromethyl-phenyl)-propionamide
Type:
Small organic molecule
Emp. Form.:
C36H33ClF3N5O5S
Mol. Mass.:
740.191
SMILES:
CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(cc1)-c1ccccc1S(=O)(=O)NC(=O)c1ccccc1Cl