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Target
Histone deacetylase 8
Ligand
BDBM50492421
Substrate
n/a
Meas. Tech.
ChEMBL_969609 (CHEMBL2406451)
IC50
4000±n/a nM
Citation
 Gryder, BE; Rood, MK; Johnson, KA; Patil, V; Raftery, ED; Yao, LP; Rice, M; Azizi, B; Doyle, DF; Oyelere, AK Histone deacetylase inhibitors equipped with estrogen receptor modulation activity. J Med Chem 56:5782-96 (2013) [PubMed]  Article 
Target
Name:
Histone deacetylase 8
Synonyms:
HD8 | HDAC8 | HDAC8_HUMAN | HDACL1 | Histone deacetylase 8 (HDAC-8) | Human HDAC8
Type:
Enzyme
Mol. Mass.:
41749.60
Organism:
Homo sapiens (Human)
Description:
Q9BY41
Residue:
377
Sequence:
MEEPEEPADSGQSLVPVYIYSPEYVSMCDSLAKIPKRASMVHSLIEAYALHKQMRIVKPKVASMEEMATFHTDAYLQHLQKVSQEGDDDHPDSIEYGLGYDCPATEGIFDYAAAIGGATITAAQCLIDGMCKVAINWSGGWHHAKKDEASGFCYLNDAVLGILRLRRKFERILYVDLDLHHGDGVEDAFSFTSKVMTVSLHKFSPGFFPGTGDVSDVGLGKGRYYSVNVPIQDGIQDEKYYQICESVLKEVYQAFNPKAVVLQLGADTIAGDPMCSFNMTPVGIGKCLKYILQWQLATLILGGGGYNLANTARCWTYLTGVILGKTLSSEIPDHEFFTAYGPDYVLEITPSCRPDRNEPHRIQQILNYIKGNLKHVV
  
Inhibitor
Name:
BDBM50492421
Synonyms:
CHEMBL2401845
Type:
Small organic molecule
Emp. Form.:
C26H36N4O4
Mol. Mass.:
468.5884
SMILES:
[H][C@@]12CC[C@@](O)(c3cn(CCCCCC(=O)NO)nn3)[C@@]1(C)CC[C@]1([H])c3ccc(O)cc3CC[C@@]21[H] |r|
Structure:
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