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Target
UDP-3-O-acyl-N-acetylglucosamine deacetylase
Ligand
BDBM50495313
Substrate
n/a
Meas. Tech.
ChEMBL_1283917 (CHEMBL3106530)
IC50
>200000±n/a nM
Citation
 Szermerski, M; Melesina, J; Wichapong, K; Löppenberg, M; Jose, J; Sippl, W; Holl, R Synthesis, biological evaluation and molecular docking studies of benzyloxyacetohydroxamic acids as LpxC inhibitors. Bioorg Med Chem 22:1016-28 (2014) [PubMed]  Article 
Target
Name:
UDP-3-O-acyl-N-acetylglucosamine deacetylase
Synonyms:
LPXC_ECOLI | UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase (LpxC) | UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase (LxpC) | UDP-3-O-acyl-GlcNAc deacetylase | asmB | envA | lpxC
Type:
Enzyme
Mol. Mass.:
33952.00
Organism:
Escherichia coli
Description:
P0A725
Residue:
305
Sequence:
MIKQRTLKRIVQATGVGLHTGKKVTLTLRPAPANTGVIYRRTDLNPPVDFPADAKSVRDTMLCTCLVNEHDVRISTVEHLNAALAGLGIDNIVIEVNAPEIPIMDGSAAPFVYLLLDAGIDELNCAKKFVRIKETVRVEDGDKWAEFKPYNGFSLDFTIDFNHPAIDSSNQRYAMNFSADAFMRQISRARTFGFMRDIEYLQSRGLCLGGSFDCAIVVDDYRVLNEDGLRFEDEFVRHKMLDAIGDLFMCGHNIIGAFTAYKSGHALNNKLLQAVLAKQEAWEYVTFQDDAELPLAFKAPSAVLA
  
Inhibitor
Name:
BDBM50495313
Synonyms:
CHEMBL3103558
Type:
Small organic molecule
Emp. Form.:
C15H21NO4Si
Mol. Mass.:
307.417
SMILES:
[#6][Si;v4]([#6])([#6])C#Cc1ccc(cc1)-[#6@H](-[#6]-[#8])-[#8]-[#6]-[#6](=O)-[#7]-[#8] |r|
Structure:
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