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Target
Muscarinic acetylcholine receptor M1
Ligand
BDBM50048580
Substrate
n/a
Meas. Tech.
ChEMBL_138810 (CHEMBL748241)
IC50
1300±n/a nM
Citation
 Klein, JT; Davis, L; Olsen, GE; Wong, GS; Huger, FP; Smith, CP; Petko, WW; Cornfeldt, M; Wilker, JC; Blitzer, RD; Landau, E; Haroutunian, V; Martin, LL; Effland, RC Synthesis and structure-activity relationships of N-propyl-N-(4-pyridinyl)-1H-indol-1-amine (besipirdine) and related analogs as potential therapeutic agents for Alzheimer's disease. J Med Chem 39:570-81 (1996) [PubMed]  Article 
Target
Name:
Muscarinic acetylcholine receptor M1
Synonyms:
ACM1_RAT | Cholinergic, muscarinic M1 | Chrm-1 | Chrm1 | cholinergic receptor, muscarinic 1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
51390.46
Organism:
RAT
Description:
P08482
Residue:
460
Sequence:
MNTSVPPAVSPNITVLAPGKGPWQVAFIGITTGLLSLATVTGNLLVLISFKVNTELKTVNNYFLLSLACADLIIGTFSMNLYTTYLLMGHWALGTLACDLWLALDYVASNASVMNLLLISFDRYFSVTRPLSYRAKRTPRRAALMIGLAWLVSFVLWAPAILFWQYLVGERTVLAGQCYIQFLSQPIITFGTAMAAFYLPVTVMCTLYWRIYRETENRARELAALQGSETPGKGGGSSSSSERSQPGAEGSPESPPGRCCRCCRAPRLLQAYSWKEEEEEDEGSMESLTSSEGEEPGSEVVIKMPMVDSEAQAPTKQPPKSSPNTVKRPTKKGRDRGGKGQKPRGKEQLAKRKTFSLVKEKKAARTLSAILLAFILTWTPYNIMVLVSTFCKDCVPETLWELGYWLCYVNSTVNPMCYALCNKAFRDTFRLLLLCRWDKRRWRKIPKRPGSVHRTPSRQC
  
Inhibitor
Name:
BDBM50048580
Synonyms:
CHEMBL29835 | Indol-1-yl-propyl-pyridin-4-yl-amine | Indol-1-yl-propyl-pyridin-4-yl-amine(Besipirdine)
Type:
Small organic molecule
Emp. Form.:
C16H17N3
Mol. Mass.:
251.3263
SMILES:
CCCN(c1ccncc1)n1ccc2ccccc12
Structure:
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