Reaction Details Report a problem with these data
Target
Carbonic anhydrase 4
Ligand
BDBM50500023
Substrate
n/a
Meas. Tech.
ChEMBL_1541744 (CHEMBL3745426)
Ki
496±n/a nM
Citation
 El-Azab, AS; Abdel-Aziz, AA; Ayyad, RR; Ceruso, M; Supuran, CT Inhibition of carbonic anhydrase isoforms I, II, IV, VII and XII with carboxylates and sulfonamides incorporating phthalimide/phthalic anhydride scaffolds. Bioorg Med Chem 24:20-5 (2016) [PubMed]  Article 
Target
Name:
Carbonic anhydrase 4
Synonyms:
CA-IV | CA4 | CAH4_HUMAN | Carbonate dehydratase IV | Carbonic anhydrase | Carbonic anhydrase 4 (CA IV) | Carbonic anhydrase IV (CA IV)
Type:
Enzyme
Mol. Mass.:
35037.98
Organism:
Homo sapiens (Human)
Description:
P22748
Residue:
312
Sequence:
MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR
  
Inhibitor
Name:
BDBM50500023
Synonyms:
CHEMBL3741601
Type:
Small organic molecule
Emp. Form.:
C24H19N3O7S
Mol. Mass.:
493.489
SMILES:
NS(=O)(=O)c1ccc(CCN2C(=O)c3ccc(cc3C2=O)C(=O)Nc2ccccc2C(O)=O)cc1
Structure:
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