Reaction Details Report a problem with these data
Target
Carbonic anhydrase 7
Ligand
BDBM50500027
Substrate
n/a
Meas. Tech.
ChEMBL_1541745 (CHEMBL3745427)
Ki
3.2±n/a nM
Citation
 El-Azab, AS; Abdel-Aziz, AA; Ayyad, RR; Ceruso, M; Supuran, CT Inhibition of carbonic anhydrase isoforms I, II, IV, VII and XII with carboxylates and sulfonamides incorporating phthalimide/phthalic anhydride scaffolds. Bioorg Med Chem 24:20-5 (2016) [PubMed]  Article 
Target
Name:
Carbonic anhydrase 7
Synonyms:
CA-VII | CA7 | CAH7_HUMAN | Carbonate dehydratase VII | Carbonic anhydrase | Carbonic anhydrase VII | Carbonic anhydrase VII (CA VII)
Type:
Enzyme
Mol. Mass.:
29664.11
Organism:
Homo sapiens (Human)
Description:
Human cloned isozyme.
Residue:
264
Sequence:
MTGHHGWGYGQDDGPSHWHKLYPIAQGDRQSPINIISSQAVYSPSLQPLELSYEACMSLSITNNGHSVQVDFNDSDDRTVVTGGPLEGPYRLKQFHFHWGKKHDVGSEHTVDGKSFPSELHLVHWNAKKYSTFGEAASAPDGLAVVGVFLETGDEHPSMNRLTDALYMVRFKGTKAQFSCFNPKCLLPASRHYWTYPGSLTTPPLSESVTWIVLREPICISERQMGKFRSLLFTSEDDERIHMVNNFRPPQPLKGRVVKASFRA
  
Inhibitor
Name:
BDBM50500027
Synonyms:
CHEMBL3740074
Type:
Small organic molecule
Emp. Form.:
C23H16N2O5
Mol. Mass.:
400.3835
SMILES:
OC(=O)c1ccccc1NC(=O)c1ccc2C(=O)N(Cc3ccccc3)C(=O)c2c1
Structure:
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