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Target
Tubulin beta-2B chain
Ligand
BDBM50059096
Substrate
n/a
Meas. Tech.
ChEMBL_211874 (CHEMBL819256)
IC50
32000±n/a nM
Citation
 Chen, K; Kuo, SC; Hsieh, MC; Mauger, A; Lin, CM; Hamel, E; Lee, KH Antitumor agents. 174. 2',3',4',5,6,7-Substituted 2-phenyl-1,8-naphthyridin-4-ones: their synthesis, cytotoxicity, and inhibition of tubulin polymerization. J Med Chem 40:2266-75 (1997) [PubMed]  Article 
Target
Name:
Tubulin beta-2B chain
Synonyms:
TBB2B_BOVIN | TUBB2B | Tubulin | Tubulin beta chain
Type:
PROTEIN
Mol. Mass.:
49932.38
Organism:
Bos taurus
Description:
ChEMBL_211651
Residue:
445
Sequence:
MREIVHIQAGQCGNQIGAKFWEVISDEHGIDPTGSYHGDSDLQLERINVYYNEATGNKYVPRAILVDLEPGTMDSVRSGPFGQIFRPDNFVFGQSGAGNNWAKGHYTEGAELVDSVLDVVRKESESCDCLQGFQLTHSLGGGTGSGMGTLLISKIREEYPDRIMNTFSVMPSPKVSDTVVEPYNATLSVHQLVENTDETYCIDNEALYDICFRTLKLTTPTYGDLNHLVSATMSGVTTCLRFPGQLNADLRKLAVNMVPFPRLHFFMPGFAPLTSRGSQQYRALTVPELTQQMFDSKNMMAACDPRHGRYLTVAAIFRGRMSMKEVDEQMLNVQNKNSSYFVEWIPNNVKTAVCDIPPRGLKMSATFIGNSTAIQELFKRISEQFTAMFRRKAFLHWYTGEGMDEMEFTEAESNMNDLVSEYQQYQDATADEQGEFEEEEGEDEA
  
Inhibitor
Name:
BDBM50059096
Synonyms:
2-(4-Chloro-phenyl)-5,7-dimethyl-1H-[1,8]naphthyridin-4-one | CHEMBL75041
Type:
Small organic molecule
Emp. Form.:
C16H13ClN2O
Mol. Mass.:
284.74
SMILES:
Cc1cc(C)c2c(O)cc(nc2n1)-c1ccc(Cl)cc1
Structure:
Search PDB for entries with ligand similarity: