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Target
Muscarinic acetylcholine receptor M1
Ligand
BDBM50062588
Substrate
n/a
Meas. Tech.
ChEMBL_138688 (CHEMBL749925)
IC50
22.3±n/a nM
Citation
 Ward, JS; Merritt, L; Calligaro, DO; Bymaster, FP; Shannon, HE; Mitch, CH; Whitesitt, C; Brunsting, D; Sheardown, MJ; Olesen, PH; Swedberg, MD; Jeppesen, L; Sauerberg, P 1,2,5-Thiadiazole analogues of aceclidine as potent m1 muscarinic agonists. J Med Chem 41:379-92 (1998) [PubMed]  Article 
Target
Name:
Muscarinic acetylcholine receptor M1
Synonyms:
ACM1_RAT | Cholinergic, muscarinic M1 | Chrm-1 | Chrm1 | cholinergic receptor, muscarinic 1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
51390.46
Organism:
RAT
Description:
P08482
Residue:
460
Sequence:
MNTSVPPAVSPNITVLAPGKGPWQVAFIGITTGLLSLATVTGNLLVLISFKVNTELKTVNNYFLLSLACADLIIGTFSMNLYTTYLLMGHWALGTLACDLWLALDYVASNASVMNLLLISFDRYFSVTRPLSYRAKRTPRRAALMIGLAWLVSFVLWAPAILFWQYLVGERTVLAGQCYIQFLSQPIITFGTAMAAFYLPVTVMCTLYWRIYRETENRARELAALQGSETPGKGGGSSSSSERSQPGAEGSPESPPGRCCRCCRAPRLLQAYSWKEEEEEDEGSMESLTSSEGEEPGSEVVIKMPMVDSEAQAPTKQPPKSSPNTVKRPTKKGRDRGGKGQKPRGKEQLAKRKTFSLVKEKKAARTLSAILLAFILTWTPYNIMVLVSTFCKDCVPETLWELGYWLCYVNSTVNPMCYALCNKAFRDTFRLLLLCRWDKRRWRKIPKRPGSVHRTPSRQC
  
Inhibitor
Name:
BDBM50062588
Synonyms:
3-(3-Butoxy-pyrazin-2-yloxy)-1-aza-bicyclo[2.2.2]octane | CHEMBL340402
Type:
Small organic molecule
Emp. Form.:
C15H23N3O2
Mol. Mass.:
277.362
SMILES:
CCCCOc1nccnc1OC1CN2CCC1CC2 |(8.29,-14.19,;9.45,-13.17,;9.13,-11.65,;10.29,-10.62,;9.97,-9.12,;11.3,-8.36,;12.65,-9.13,;13.98,-8.36,;13.98,-6.81,;12.65,-6.05,;11.32,-6.82,;9.99,-6.05,;8.64,-6.82,;8.64,-8.36,;7.31,-9.12,;6,-8.36,;6,-6.82,;7.31,-6.04,;6.56,-7.38,;8.08,-7.78,)|
Structure:
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