Reaction Details Report a problem with these data
Target
Taste receptor type 2 member 8
Ligand
BDBM211356
Substrate
n/a
Meas. Tech.
ChEMBL_1845977 (CHEMBL4346404)
IC50
20±n/a nM
Citation
 Fotsing, JR; Darmohusodo, V; Patron, AP; Ching, BW; Brady, T; Arellano, M; Chen, Q; Davis, TJ; Liu, H; Servant, G; Zhang, L; Williams, M; Saganich, M; Ditschun, T; Tachdjian, C; Karanewsky, DS Discovery and Development of S6821 and S7958 as Potent TAS2R8 Antagonists. J Med Chem 63:4957-4977 (2020) [PubMed]  Article 
Target
Name:
Taste receptor type 2 member 8
Synonyms:
T2R8 | TA2R8_HUMAN | TAS2R8 | TRB5 | Taste receptor family B member 5 | Taste receptor type 2 member 8 (T2R8)
Type:
n/a
Mol. Mass.:
35897.08
Organism:
Homo sapiens (Human)
Description:
Q9NYW2
Residue:
309
Sequence:
MFSPADNIFIILITGEFILGILGNGYIALVNWIDWIKKKKISTVDYILTNLVIARICLISVMVVNGIVIVLNPDVYTKNKQQIVIFTFWTFANYLNMWITTCLNVFYFLKIASSSHPLFLWLKWKIDMVVHWILLGCFAISLLVSLIAAIVLSCDYRFHAIAKHKRNITEMFHVSKIPYFEPLTLFNLFAIVPFIVSLISFFLLVRSLWRHTKQIKLYATGSRDPSTEVHVRAIKTMTSFIFFFFLYYISSILMTFSYLMTKYKLAVEFGEIAAILYPLGHSLILIVLNNKLRQTFVRMLTCRKIACMI
  
Inhibitor
Name:
BDBM211356
Synonyms:
US9247759, 12-7
Type:
Small organic molecule
Emp. Form.:
C20H21N5O4
Mol. Mass.:
395.4118
SMILES:
C[C@H]1N(Cc2cccc(O)c2)C(=O)N(C1=O)c1cnn(Cc2c(C)noc2C)c1 |r|
Structure:
Search PDB for entries with ligand similarity: