Reaction Details Report a problem with these data
Target
Cannabinoid receptor 1
Ligand
BDBM50513133
Substrate
n/a
Meas. Tech.
ChEMBL_1852067 (CHEMBL4352691)
EC50
1530±n/a nM
Citation
 Tseng, CC; Baillie, G; Donvito, G; Mustafa, MA; Juola, SE; Zanato, C; Massarenti, C; Dall'Angelo, S; Harrison, WTA; Lichtman, AH; Ross, RA; Zanda, M; Greig, IR The Trifluoromethyl Group as a Bioisosteric Replacement of the Aliphatic Nitro Group in CB J Med Chem 62:5049-5062 (2019) [PubMed]  Article 
Target
Name:
Cannabinoid receptor 1
Synonyms:
CANN6 | CANNABINOID CB1 | CB-R | CB1 | CNR | CNR1 | CNR1_HUMAN | Cannabinoid CB1 receptor | Cannabinoid receptor | Cannabinoid receptor 1 (CB1) | Cannabinoid receptor 1 (brain)
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
52868.96
Organism:
Homo sapiens (Human)
Description:
P21554
Residue:
472
Sequence:
MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL
  
Inhibitor
Name:
BDBM50513133
Synonyms:
CHEMBL4533821
Type:
Small organic molecule
Emp. Form.:
C20H15ClN2O2S
Mol. Mass.:
382.863
SMILES:
[O-][N+](=O)CC(c1cccs1)c1c([nH]c2cc(Cl)ccc12)-c1ccccc1
Structure:
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