Target
Cathepsin S
Ligand
BDBM50514673
Substrate
n/a
Meas. Tech.
ChEMBL_1858198 (CHEMBL4358927)
Ki
1800±n/a nM
Citation
 Chenna, BCLi, LMellott, DMZhai, XSiqueira-Neto, JLCalvet Alvarez, CBernatchez, JADesormeaux, EAlvarez Hernandez, EGomez, JMcKerrow, JHCruz-Reyes, JMeek, TD Peptidomimetic Vinyl Heterocyclic Inhibitors of Cruzain Effect Antitrypanosomal Activity. J Med Chem 63:3298-3316 (2020) [PubMed]  Article 
Target
Name:
Cathepsin S
Synonyms:
CATS_HUMAN | CTSS | Cathepsin S (Cat S) | cathepsin S preproprotein
Type:
Protein
Mol. Mass.:
37507.38
Organism:
Homo sapiens (Human)
Description:
P25774
Residue:
331
Sequence:
MKRLVCVLLVCSSAVAQLHKDPTLDHHWHLWKKTYGKQYKEKNEEAVRRLIWEKNLKFVMLHNLEHSMGMHSYDLGMNHLGDMTSEEVMSLMSSLRVPSQWQRNITYKSNPNRILPDSVDWREKGCVTEVKYQGSCGACWAFSAVGALEAQLKLKTGKLVSLSAQNLVDCSTEKYGNKGCNGGFMTTAFQYIIDNKGIDSDASYPYKAMDQKCQYDSKYRAATCSKYTELPYGREDVLKEAVANKGPVSVGVDARHPSFFLYRSGVYYEPSCTQNVNHGVLVVGYGDLNGKEYWLVKNSWGHNFGEEGYIRMARNKGNHCGIASFPSYPEI
  
Inhibitor
Name:
BDBM50514673
Synonyms:
CHEMBL4544942
Type:
Small organic molecule
Emp. Form.:
C32H31N3O3
Mol. Mass.:
505.6068
SMILES:
O=C(N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1ccccc1)\C=C\c1ccccn1)OCc1ccccc1 |r|
Structure:
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