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Target
Glutaminase kidney isoform, mitochondrial
Ligand
BDBM50517271
Substrate
n/a
Meas. Tech.
ChEMBL_1868737 (CHEMBL4369803)
IC50
>13000±n/a nM
Citation
 Chen, Z; Li, D; Xu, N; Fang, J; Yu, Y; Hou, W; Ruan, H; Zhu, P; Ma, R; Lu, S; Cao, D; Wu, R; Ni, M; Zhang, W; Su, W; Ruan, BH Novel 1,3,4-Selenadiazole-Containing Kidney-Type Glutaminase Inhibitors Showed Improved Cellular Uptake and Antitumor Activity. J Med Chem 62:589-603 (2019) [PubMed]  Article 
Target
Name:
Glutaminase kidney isoform, mitochondrial
Synonyms:
GLS | GLS1 | GLSK_HUMAN | Glutaminase 1 | K-glutaminase | KIAA0838 | L-glutamine amidohydrolase
Type:
Protein
Mol. Mass.:
73471.89
Organism:
Homo sapiens (Human)
Description:
O94925
Residue:
669
Sequence:
MMRLRGSGMLRDLLLRSPAGVSATLRRAQPLVTLCRRPRGGGRPAAGPAAAARLHPWWGGGGWPAEPLARGLSSSPSEILQELGKGSTHPQPGVSPPAAPAAPGPKDGPGETDAFGNSEGKELVASGENKIKQGLLPSLEDLLFYTIAEGQEKIPVHKFITALKSTGLRTSDPRLKECMDMLRLTLQTTSDGVMLDKDLFKKCVQSNIVLLTQAFRRKFVIPDFMSFTSHIDELYESAKKQSGGKVADYIPQLAKFSPDLWGVSVCTVDGQRHSTGDTKVPFCLQSCVKPLKYAIAVNDLGTEYVHRYVGKEPSGLRFNKLFLNEDDKPHNPMVNAGAIVVTSLIKQGVNNAEKFDYVMQFLNKMAGNEYVGFSNATFQSERESGDRNFAIGYYLKEKKCFPEGTDMVGILDFYFQLCSIEVTCESASVMAATLANGGFCPITGERVLSPEAVRNTLSLMHSCGMYDFSGQFAFHVGLPAKSGVAGGILLVVPNVMGMMCWSPPLDKMGNSVKGIHFCHDLVSLCNFHNYDNLRHFAKKLDPRREGGDQRVKSVINLLFAAYTGDVSALRRFALSAMDMEQRDYDSRTALHVAAAEGHVEVVKFLLEACKVNPFPKDRWNNTPMDEALHFGHHDVFKILQEYQVQYTPQGDSDNGKENQTVHKNLDGLL
  
Inhibitor
Name:
BDBM50517271
Synonyms:
CHEMBL4565066
Type:
Small organic molecule
Emp. Form.:
C22H24N6O2SSe2
Mol. Mass.:
594.45
SMILES:
[#6]-[#8]-c1ccc(-[#7]-c2nnc(-[#6]-[#6]-[#16]-[#6]-[#6]-c3nnc(-[#7]-c4ccc(-[#8]-[#6])cc4)[se;v2]3)[se;v2]2)cc1
Structure:
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