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Target
Spindlin-1
Ligand
BDBM50519514
Substrate
n/a
Meas. Tech.
ChEMBL_1875896 (CHEMBL4377290)
IC50
77±n/a nM
Citation
 Xiong, Y; Greschik, H; Johansson, C; Seifert, L; Bacher, J; Park, KS; Babault, N; Martini, M; Fagan, V; Li, F; Chau, I; Christott, T; Dilworth, D; Barsyte-Lovejoy, D; Vedadi, M; Arrowsmith, CH; Brennan, P; Fedorov, O; Jung, M; Farnie, G; Liu, J; Oppermann, U; Schüle, R; Jin, J Discovery of a Potent and Selective Fragment-like Inhibitor of Methyllysine Reader Protein Spindlin 1 (SPIN1). J Med Chem 62:8996-9007 (2019) [PubMed]  Article 
Target
Name:
Spindlin-1
Synonyms:
OCR | Ovarian cancer-related protein | SPIN | SPIN1 | SPIN1_HUMAN | Spindlin-1 | Spindlin1
Type:
PROTEIN
Mol. Mass.:
29602.24
Organism:
Homo sapiens
Description:
ChEMBL_119259
Residue:
262
Sequence:
MKTPFGKTPGQRSRADAGHAGVSANMMKKRTSHKKHRSSVGPSKPVSQPRRNIVGCRIQHGWKEGNGPVTQWKGTVLDQVPVNPSLYLIKYDGFDCVYGLELNKDERVSALEVLPDRVATSRISDAHLADTMIGKAVEHMFETEDGSKDEWRGMVLARAPVMNTWFYITYEKDPVLYMYQLLDDYKEGDLRIMPDSNDSPPAEREPGEVVDSLVGKQVEYAKEDGSKRTGMVIHQVEAKPSVYFIKFDDDFHIYVYDLVKTS
  
Inhibitor
Name:
BDBM50519514
Synonyms:
CHEMBL4552020
Type:
Small organic molecule
Emp. Form.:
C20H27N3O2
Mol. Mass.:
341.4473
SMILES:
COc1c(CN)cc(CN)cc1OCCCN1Cc2ccccc2C1
Structure:
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