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Target
Histamine H3 receptor
Ligand
BDBM50074075
Substrate
n/a
Meas. Tech.
ChEMBL_86761 (CHEMBL698661)
Ki
22±n/a nM
Citation
 Sasse, A; Kiec-Kononowicz, K; Stark, H; Motyl, M; Reidemeister, S; Ganellin, CR; Ligneau, X; Schwartz, JC; Schunack, W Development of chiral N-alkylcarbamates as new leads for potent and selective H3-receptor antagonists: synthesis, capillary electrophoresis, and in vitro and oral in vivo activity. J Med Chem 42:593-600 (1999) [PubMed]  Article 
Target
Name:
Histamine H3 receptor
Synonyms:
HH3R | HRH3_RAT | Hrh3
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
48607.98
Organism:
Rattus norvegicus (rat)
Description:
n/a
Residue:
445
Sequence:
MERAPPDGLMNASGTLAGEAAAAGGARGFSAAWTAVLAALMALLIVATVLGNALVMLAFVADSSLRTQNNFFLLNLAISDFLVGAFCIPLYVPYVLTGRWTFGRGLCKLWLVVDYLLCASSVFNIVLISYDRFLSVTRAVSYRAQQGDTRRAVRKMALVWVLAFLLYGPAILSWEYLSGGSSIPEGHCYAEFFYNWYFLITASTLEFFTPFLSVTFFNLSIYLNIQRRTRLRLDGGREAGPEPPPDAQPSPPPAPPSCWGCWPKGHGEAMPLHRYGVGEAGPGVEAGEAALGGGSGGGAAASPTSSSGSSSRGTERPRSLKRGSKPSASSASLEKRMKMVSQSITQRFRLSRDKKVAKSLAIIVSIFGLCWAPYTLLMIIRAACHGRCIPDYWYETSFWLLWANSAVNPVLYPLCHYSFRRAFTKLLCPQKLKVQPHGSLEQCWK
  
Inhibitor
Name:
BDBM50074075
Synonyms:
(3-Methylsulfanyl-propyl)-carbamic acid 3-(1H-imidazol-4-yl)-propyl ester; compound with (E)-but-2-enedioic acid | CHEMBL153963
Type:
Small organic molecule
Emp. Form.:
C11H19N3O2S
Mol. Mass.:
257.352
SMILES:
CSCCCNC(=O)OCCCc1cnc[nH]1
Structure:
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