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Target
Reverse transcriptase
Ligand
BDBM50524090
Substrate
n/a
Meas. Tech.
ChEMBL_1891833 (CHEMBL4393754)
IC50
20000±n/a nM
Citation
 Namasivayam, V; Vanangamudi, M; Kramer, VG; Kurup, S; Zhan, P; Liu, X; Kongsted, J; Byrareddy, SN The Journey of HIV-1 Non-Nucleoside Reverse Transcriptase Inhibitors (NNRTIs) from Lab to Clinic. J Med Chem 62:4851-4883 (2019) [PubMed]  Article 
Target
Name:
Reverse transcriptase
Synonyms:
n/a
Type:
Protein
Mol. Mass.:
29598.37
Organism:
Human immunodeficiency virus 1
Description:
Q9WKE8
Residue:
254
Sequence:
PISPITVPVKLKPGMDGPKVKQWPLTEEKIKALTEICTEMEKEGKIEKIGPENPYNTPVFAIKKKDSTKWRKVVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPLDKDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVIYQYMDDLYVGSDLEIEQHRAKIEELRQHLLRWGFTTPDKKHQKEPPFLWMGYELHPDKWTVQPIVLPEKDSWTVN
  
Inhibitor
Name:
BDBM50524090
Synonyms:
CHEMBL1192060
Type:
Small organic molecule
Emp. Form.:
C21H30N4O
Mol. Mass.:
354.4891
SMILES:
CCNc1cccnc1N1CCN(Cc2cc(C)c(OC)c(C)c2)CC1
Structure:
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