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Target
Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha
Ligand
BDBM50527927
Substrate
n/a
Meas. Tech.
ChEMBL_1904111 (CHEMBL4406333)
IC50
270±n/a nM
Citation
 Manz, TD; Sivakumaren, SC; Ferguson, FM; Zhang, T; Yasgar, A; Seo, HS; Ficarro, SB; Card, JD; Shim, H; Miduturu, CV; Simeonov, A; Shen, M; Marto, JA; Dhe-Paganon, S; Hall, MD; Cantley, LC; Gray, NS Discovery and Structure-Activity Relationship Study of ( J Med Chem 63:4880-4895 (2020) [PubMed]  Article 
Target
Name:
Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha
Synonyms:
1-phosphatidylinositol 5-phosphate 4-kinase 2-alpha | 2.7.1.149 | Diphosphoinositide kinase 2-alpha | PI(5)P 4-kinase type II alpha | PI42A_HUMAN | PI5P4KA | PIP4K2A | PIP4KII-alpha | PIP5K2 | PIP5K2A | PIP5KIII | Phosphatidylinositol 5-phosphate 4-kinase type II alpha | Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha | Phosphatidylinositol-5-phosphate 4-kinase type-2 alpha | PtdIns(4)P-5-kinase B isoform | PtdIns(4)P-5-kinase C isoform | PtdIns(5)P-4-kinase isoform 2-alpha
Type:
PROTEIN
Mol. Mass.:
46228.59
Organism:
Homo sapiens
Description:
ChEMBL_104274
Residue:
406
Sequence:
MATPGNLGSSVLASKTKTKKKHFVAQKVKLFRASDPLLSVLMWGVNHSINELSHVQIPVMLMPDDFKAYSKIKVDNHLFNKENMPSHFKFKEYCPMVFRNLRERFGIDDQDFQNSLTRSAPLPNDSQARSGARFHTSYDKRYIIKTITSEDVAEMHNILKKYHQYIVECHGITLLPQFLGMYRLNVDGVEIYVIVTRNVFSHRLSVYRKYDLKGSTVAREASDKEKAKELPTLKDNDFINEGQKIYIDDNNKKVFLEKLKKDVEFLAQLKLMDYSLLVGIHDVERAEQEEVECEENDGEEEGESDGTHPVGTPPDSPGNTLNSSPPLAPGEFDPNIDVYGIKCHENSPRKEVYFMAIIDILTHYDAKKKAAHAAKTVKHGAGAEISTVNPEQYSKRFLDFIGHILT
  
Inhibitor
Name:
BDBM50527927
Synonyms:
CHEMBL4436648
Type:
Small organic molecule
Emp. Form.:
C16H14N4O3S2
Mol. Mass.:
374.437
SMILES:
CS(=O)(=O)Nc1ccc(cc1)-c1cncc(\C=C2/SC(=N)NC2=O)c1
Structure:
Search PDB for entries with ligand similarity: