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Target
Tyrosine-protein phosphatase non-receptor type 1
Ligand
BDBM50085964
Substrate
n/a
Meas. Tech.
ChEMBL_221212 (CHEMBL842437)
IC50
46000±n/a nM
Citation
 Malamas, MS; Sredy, J; Gunawan, I; Mihan, B; Sawicki, DR; Seestaller, L; Sullivan, D; Flam, BR New azolidinediones as inhibitors of protein tyrosine phosphatase 1B with antihyperglycemic properties. J Med Chem 43:995-1010 (2000) [PubMed]  Article 
Target
Name:
Tyrosine-protein phosphatase non-receptor type 1
Synonyms:
PTN1_RAT | PTP-1B | PTPase 1B | Protein-Tyrosine Phosphatase 1B (PTP1B) | Ptpn1 | Tyrosine-protein phosphatase, non-receptor type 1
Type:
Enzyme
Mol. Mass.:
49669.91
Organism:
Rattus norvegicus (rat)
Description:
n/a
Residue:
432
Sequence:
MEMEKEFEQIDKAGNWAAIYQDIRHEASDFPCRIAKLPKNKNRNRYRDVSPFDHSRIKLHQEDNDYINASLIKMEEAQRSYILTQGPLPNTCGHFWEMVWEQKSRGVVMLNRIMEKGSLKCAQYWPQKEEKEMVFDDTNLKLTLISEDVKSYYTVRQLELENLATQEAREILHFHYTTWPDFGVPESPASFLNFLFKVRESGSLSPEHGPIVVHCSAGIGRSGTFCLADTCLLLMDKRKDPSSVDIKKVLLEMRRFRMGLIQTADQLRFSYLAVIEGAKFIMGDSSVQDQWKELSHEDLEPPPEHVPPPPRPPKRTLEPHNGKCKELFSNHQWVSEESCEDEDILAREESRAPSIAVHSMSSMSQDTEVRKRMVGGGLQSAQASVPTEEELSPTEEEQKAHRPVHWKPFLVNVCMATALATGAYLCYRVCFH
  
Inhibitor
Name:
BDBM50085964
Synonyms:
5-(3-{3-[5-Methyl-2-(4-trifluoromethoxy-phenyl)-oxazol-4-ylmethoxy]-phenyl}-but-2-enyl)-oxazolidine-2,4-dione | CHEMBL7223
Type:
Small organic molecule
Emp. Form.:
C25H21F3N2O6
Mol. Mass.:
502.4392
SMILES:
C\C(=C/Cc1oc(=O)[nH]c1O)c1cccc(OCc2nc(oc2C)-c2ccc(OC(F)(F)F)cc2)c1
Structure:
Search PDB for entries with ligand similarity: