Reaction Details Report a problem with these data
Target
Transcriptional enhancer factor TEF-5
Ligand
BDBM50531838
Substrate
n/a
Meas. Tech.
ChEMBL_1921067 (CHEMBL4423912)
IC50
44000±n/a nM
Citation
 Smith, SA; Sessions, RB; Shoemark, DK; Williams, C; Ebrahimighaei, R; McNeill, MC; Crump, MP; McKay, TR; Harris, G; Newby, AC; Bond, M Antiproliferative and Antimigratory Effects of a Novel YAP-TEAD Interaction Inhibitor Identified Using in Silico Molecular Docking. J Med Chem 62:1291-1305 (2019) [PubMed]  Article 
Target
Name:
Transcriptional enhancer factor TEF-5
Synonyms:
DTEF-1 | TEA domain family member 3 | TEAD-3 | TEAD3 | TEAD3_HUMAN | TEAD5 | TEF5 | Transcriptional enhancer factor TEF-5
Type:
PROTEIN
Mol. Mass.:
48683.38
Organism:
Homo sapiens
Description:
ChEMBL_119185
Residue:
435
Sequence:
MASNSWNASSSPGEAREDGPEGLDKGLDNDAEGVWSPDIEQSFQEALAIYPPCGRRKIILSDEGKMYGRNELIARYIKLRTGKTRTRKQVSSHIQVLARKKVREYQVGIKAMNLDQVSKDKALQSMASMSSAQIVSASVLQNKFSPPSPLPQAVFSTSSRFWSSPPLLGQQPGPSQDIKPFAQPAYPIQPPLPPTLSSYEPLAPLPSAAASVPVWQDRTIASSRLRLLEYSAFMEVQRDPDTYSKHLFVHIGQTNPAFSDPPLEAVDVRQIYDKFPEKKGGLKELYEKGPPNAFFLVKFWADLNSTIQEGPGAFYGVSSQYSSADSMTISVSTKVCSFGKQVVEKVETEYARLENGRFVYRIHRSPMCEYMINFIHKLKHLPEKYMMNSVLENFTILQVVTSRDSQETLLVIAFVFEVSTSEHGAQHHVYKLVKD
  
Inhibitor
Name:
BDBM50531838
Synonyms:
Pirazidol | Pirlindole
Type:
Small organic molecule
Emp. Form.:
C15H18N2
Mol. Mass.:
226.3168
SMILES:
Cc1ccc2n3CCNC4CCCc(c34)c2c1
Structure:
Search PDB for entries with ligand similarity: